ArticleBiomolecules2020
New Lipidyl-Cyclodextrins Obtained by Ring Opening of Methyl Oleate Epoxide Using Ball Milling.
Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mass Spectrometry of Esterified Cyclodextrins.Molecules (Basel, Switzerland) · 2023Review
- Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives.Molecules (Basel, Switzerland) · 2023Review
- Mechanochemistry and oleochemistry: a green combination for the production of high-value small chemicals.Frontiers in chemistry · 2023Review
- Mass Spectrometry, Ion Mobility Separation and Molecular Modelling: A Powerful Combination for the Structural Characterisation of Substituted Cyclodextrins Mixtures.International journal of molecular sciences · 2022Article
- Toward a Greener World-Cyclodextrin Derivatization by Mechanochemistry.Molecules (Basel, Switzerland) · 2021Review
- Peering into the Kaleidoscope of Cyclodextrins.Biomolecules · 2021Article
- GM1 Oligosaccharide Crosses the Human Blood-Brain Barrier In Vitro by a Paracellular Route.International journal of molecular sciences · 2020Article
- Particle size effect in the mechanically assisted synthesis of β-cyclodextrin mesitylene sulfonate.Beilstein journal of organic chemistry · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Bearing grafts based on fatty esters derivatives, lipidyl-cyclodextrins (L-CDs) are compounds able to form water-soluble nano-objects. In this context, bicatenary biobased lipidic-cyclodextrins of low DS were easily synthesized from a fatty ester epoxide by means of alternative methods (ball-milling conditions, use of enzymes). The ring opening reaction of methyl oleate epoxide needs ball-milling and is highly specific of cyclodextrins in solventless conditions. L-CDs are thus composed of complex mixtures that were deciphered by an extensive structural analysis using mainly mass spectrometry and NMR spectroscopy. In addition, as part of their potential use as vectors of active drugs, these products were submitted to an integrity study on in vitro model of the blood-brain-barrier (BBB) and the intestinal epithelium. No toxicity has been observed, suggesting that applications for the vectorization of active ingredients can be expected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.