Evidence map›Paper›PMID 32092979›Full record

ArticleJournal of clinical medicine2020

TIPS Modification in the Management of Shunt-Induced Hepatic Encephalopathy: Analysis of Predictive Factors and Outcome with Shunt Modification.

Philipp Schindler, Leon Seifert, Max Masthoff, Arne Riegel, Michael Köhler, Christian Wilms, Hartmut H Schmidt, Hauke Heinzow, Moritz Wildgruber

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Philipp SchindlerInstitute of Clinical Radiology, University Hospital Muenster, D-48149 Muenster, Germany.
Leon SeifertDepartment of Gastroenterology and Hepatology, University Hospital Muenster, D-48149 Muenster, Germany.
Max MasthoffInstitute of Clinical Radiology, University Hospital Muenster, D-48149 Muenster, Germany.
Arne RiegelInstitute of Clinical Radiology, University Hospital Muenster, D-48149 Muenster, Germany.
Michael KöhlerInstitute of Clinical Radiology, University Hospital Muenster, D-48149 Muenster, Germany.
Christian WilmsDepartment of Gastroenterology and Hepatology, University Hospital Muenster, D-48149 Muenster, Germany.
Hartmut H SchmidtDepartment of Gastroenterology and Hepatology, University Hospital Muenster, D-48149 Muenster, Germany.
Hauke HeinzowDepartment of Gastroenterology and Hepatology, University Hospital Muenster, D-48149 Muenster, Germany.
Moritz WildgruberInstitute of Clinical Radiology, University Hospital Muenster, D-48149 Muenster, Germany.
University Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate predictive parameters for the development of Hepatic Encephalopathy (HE) after Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement and for success of shunt modification in the management of shunt-induced HE.

methodsA retrospective analysis of all patients with TIPS (

resultsOlder patient age, increased serum creatinine and elevated International Normalized Ratio (INR) immediately after TIPS placement were independent predictors for the development of HE. In 11/20 patients (responders, 55%) undergoing shunt modification, the HE grade was improved compared with nine non-responders (45%), with no relevant recurrence of refractory ascites or variceal bleeding. A high HE grade after TIPS insertion was the only positive predictor of treatment response ( DISCUSSION: Older patient age as well as an increased serum creatinine and INR after TIPS are potential predictors for the development of HE. TIPS reduction for the treatment of TIPS-induced HE is safe, with particular benefit for patients with pronounced HE.

Indexed as

hepatic encephalopathyliver cirrhosisportasystemic shunttransjugular intrahepatic

Identifiers

PMID32092979
PMCPMC7073830
OpenAlexW3007586748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.