ArticleMarine drugs2020
Multi-Omic Profiling of
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria.Natural product reports · 2025Review
- Jaspamide/Jasplakinolide Is Synthesized byJournal of natural products · 2025Article
- The first whole-genome sequence of a prospective novel sponge-associatedF1000Research · 2025Article
- High microbiome and metabolome diversification in coexisting sponges with different bio-ecological traits.Communications biology · 2024Article
- Sterol methyltransferases in uncultured bacteria complicate eukaryotic biomarker interpretations.Nature communications · 2023Article
- Article
- Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity.Nature microbiology · 2022Article
- Bioactive Compounds from Marine Sponges and Algae: Effects on Cancer Cell Metabolome and Chemical Structures.International journal of molecular sciences · 2022Review
- Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges.Scientific reports · 2022Article
- Comparative metabolomic analysis reveals shared and unique chemical interactions in sponge holobionts.Microbiome · 2022Article
- Barrettides: A Peptide Family Specifically Produced by the Deep-Sea SpongeJournal of natural products · 2021Article
- Stereochemical Assignment and Absolute Abundance of Nonproteinogenic Amino Acid Homoarginine in Marine Sponges.ACS omega · 2021Article
- Presence of Bromotyrosine Alkaloids in Marine Sponges Is Independent of Metabolomic and Microbiome Architectures.mSystems · 2021Article
- Assessing the Diversity and Biomedical Potential of Microbes Associated With the Neptune's Cup Sponge,Frontiers in microbiology · 2021Article
- The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine SpongeFrontiers in chemistry · 2021Article
- Precursor-Guided Mining of Marine Sponge Metabolomes Lends Insight into Biosynthesis of Pyrrole-Imidazole Alkaloids.ACS chemical biology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Marine sponge holobionts, defined as filter-feeding sponge hosts together with their associated microbiomes, are prolific sources of natural products. The inventory of natural products that have been isolated from marine sponges is extensive. Here, using untargeted mass spectrometry, we demonstrate that sponges harbor a far greater diversity of low-abundance natural products that have evaded discovery. While these low-abundance natural products may not be feasible to isolate, insights into their chemical structures can be gleaned by careful curation of mass fragmentation spectra. Sponges are also some of the most complex, multi-organismal holobiont communities in the oceans. We overlay sponge metabolomes with their microbiome structures and detailed metagenomic characterization to discover candidate gene clusters that encode production of sponge-derived natural products. The multi-omic profiling strategy for sponges that we describe here enables quantitative comparison of sponge metabolomes and microbiomes to address, among other questions, the ecological relevance of sponge natural products and for the phylochemical assignment of previously undescribed sponge identities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.