ArticleNutrients2020
Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Novel loci and biomedical consequences of iron homoeostasis variation.Communications biology · 2024Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Integrative pan-cancer analysis of transferrin reveals context-dependent prognostic associations and links to immune and metabolic disease-related programs.Discover oncology · 2026Article
- Assessing causal relationships between iron level, disorders of iron metabolism, and hepatocellular carcinoma: a Mendelian randomisation study : The first author.Discover oncology · 2026Article
- Exploring the Causal Relationship Between Inflammatory Cytokines and MRI-Derived Brain Iron: A Mendelian Randomization Study.Brain and behavior · 2024Article
- Serum iron status and the risk of lung cancer: a two-sample Mendelian-randomization study.Journal of thoracic disease · 2023Article
- Using Mendelian Randomization to Study the Role of Iron in Health and Disease.International journal of molecular sciences · 2023Review
- An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses.BMC medicine · 2023Article
- Association of plasma iron with the risk of incident cancer in Chinese adults with hypertension: a nested case-control study.Frontiers in oncology · 2023Article
- Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study.Cancer epidemiology · 2022Article
- Iron status and mental disorders: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- The causal association between iron status and the risk of autism: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Distribution and Associated Factors of Hepatic Iron-A Population-Based Imaging Study.Metabolites · 2021Article
- Association between serum ferritin, incident primary liver cancer, and chronic liver disease mortality in the Linxian Nutrition Intervention Trials: A nested case-control study.Journal of gastroenterology and hepatology · 2021Article
- Pre-Clinical Insights into the Iron and Breast Cancer Hypothesis.Biomedicines · 2021Article
- Association between serum iron status and primary liver cancer risk: a Mendelian randomization analysis.Annals of translational medicine · 2021Article
- Urban-rural disparity in cancer incidence in China, 2008-2012: a cross-sectional analysis of data from 36 cancer registers.BMJ open · 2021Article
- Causal Effects of Genetically Predicted Iron Status on Sepsis: A Two-Sample Bidirectional Mendelian Randomization Study.Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank. Genetically predicted iron status was positively associated with liver cancer and inversely associated with brain cancer but not associated with overall cancer or the other 20 studied cancer sites at
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.