ArticleMicrobes and infection2020
Is COVID-19 receiving ADE from other coronaviruses?
Article in Microbes and infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04596098 (Immune Responses to COVID-19), which is not on this map. Cited by 242 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immune Responses to COVID-19 (SARS-CoV-2 Related Infection); Isolation of Human Neutralizing Monoclonal Antibodies for Therapeutics and Vaccine Design Approaches: a Prospective Monocentric Trial With Collaborative Sample Collection.
Who cites it
242 citing papers in PubMed, 6 syntheses or guidelines pooled it, 469 citations in OpenAlex.
- Does potential antibody-dependent enhancement occur during SARS-CoV-2 infection after natural infection or vaccination? A meta-analysis.BMC infectious diseases · 2022Pooled it
- Pooled it
- Effect of convalescent blood products for patients with severe acute respiratory infections of viral etiology: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- An increasing public health burden arising from children infected with SARS-CoV2: A systematic review and meta-analysis.Pediatric pulmonology · 2020Pooled it
- Can immunity during pregnancy influence SARS-CoV-2 infection? - A systematic review.Journal of reproductive immunology · 2020Pooled it
- Immunoregulation with mTOR inhibitors to prevent COVID-19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines.Journal of medical virology · 2020Pooled it
- Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine.PLoS pathogens · 2022Trial
- Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients.European journal of immunology · 2021Trial
- Review
- The Covid-19 Infection Effect on Assisted Reproductive Method Outcomes.Journal of family & reproductive health · 2024Article
- From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2.Vaccines · 2024Review
- In Vitro Antibody-Dependent Enhancement of SARS-CoV-2 Infection Could Be Abolished by Adding Human IgG.Pathogens (Basel, Switzerland) · 2023Article
- Review
- COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmission.Archives of gynecology and obstetrics · 2023Review
- Neutralizing and Enhancing Epitopes of the SARS-CoV-2 Receptor-Binding Domain (RBD) Identified by Nanobodies.Viruses · 2023Article
- Severe COVID-19: Drugs and Clinical Trials.Journal of clinical medicine · 2023Review
- COVID-19 radiograph prognosis using a deep CResNeXt network.Multimedia tools and applications · 2023Article
- Functional studies of HLA and its role in SARS-CoV-2: Stimulating T cell response and vaccine development.Life sciences · 2023Review
- Interactions between Humans and Dogs during the COVID-19 Pandemic: Recent Updates and Future Perspectives.Animals : an open access journal from MDPI · 2023Review
- First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2.Pathogens (Basel, Switzerland) · 2023Review
182 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.