Evidence map›Paper›PMID 32092350›Full record

ArticleThe Journal of investigative dermatology2020

Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15.

Hongsheng Wang, Haiqin Jiang, Rosane M B Teles, Yanqing Chen, Aiping Wu, Jing Lu, Zhimin Chen, Feiyang Ma, Matteo Pellegrini, Robert L Modlin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  7. Monocyte-Macrophage Lineage Cell Fusion.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hongsheng WangDepartment of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Haiqin JiangInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Rosane M B TelesDepartment of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA.
Yanqing ChenInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Aiping WuSuzhou Institute of Systems Medicine Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
Jing LuDepartment of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA.
Zhimin ChenInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Feiyang MaDepartment of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA.
Robert L ModlinDepartment of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA. Electronic address: rmodlin@mednet.ucla.edu.
University of California, Los Angeles · USChinese Academy of Medical Sciences & Peking Union Medical College · CNSuzhou Institute of Systems Medicine · CN

Funding

Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7M
TCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2012 to 2016
$7.8M
The skin microbiome in acneR01AR074302 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALLO, RICHARD L, MODLIN, ROBERT L · 2018 to 2022
$2.6M
IL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1M
NIAID NIH HHS R01 AI022553NIAMS NIH HHS P50 AR063020NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252NIAMS NIH HHS R01 AR074302
6 · The paper itself

Abstract

Langhans multinucleated giant cells (LGCs) are a specific type of multinucleated giant cell containing a characteristic horseshoe-shaped ring of nuclei that are present within granulomas of infectious etiology. Although cytokines that trigger macrophage activation (such as IFN-γ) induce LGC formation, it is not clear whether cytokines that trigger macrophage differentiation contribute to LGC formation. Here, we found that IL-15, a cytokine that induces M1 macrophage differentiation, programs human peripheral blood adherent cells to form LGCs. Analysis of the IL-15‒treated adherent cell transcriptome identified gene networks for T cells, DNA damage and replication, and IFN-inducible genes that correlated with IL-15 treatment and LGC-type multinucleated giant cell formation. Gene networks enriched for myeloid cells were anticorrelated with IL-15 treatment and LGC formation. Functional studies revealed that T cells were required for IL-15‒induced LGC formation, involving a direct contact with myeloid cells through CD40L-CD40 interaction and IFN-γ release. These data indicate that IL-15 induces LGC formation through the direct interaction of activated T cells and myeloid cells.

Indexed as

Macrophage ActivationCell CommunicationCells, CulturedGene Regulatory NetworksGiant Cells, LanghansHumansInterferon-gammaInterleukin-15Primary Cell CultureRNA-SeqSignal TransductionT-LymphocytesTranscriptomeIFNG protein, humanIL15 protein, humanInterferon-gammaInterleukin-15

Identifiers

PMID32092350
PMCPMC8223586
OpenAlexW3006911565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.