Evidence map›Paper›PMID 32092190›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2020

Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.

Amy W Amara, Kimberly H Wood, Allen Joop, Raima A Memon, Jennifer Pilkington, S Craig Tuggle, John Reams, Matthew J Barrett, David A Edwards, Arthur L Weltman and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 7 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 7 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Effects of High-Intensity Interval Training on Sleep: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  8. Trial
  9. Trial
  10. Lifestyle medicine for neuroprotection: evidence and implementation in Asian contexts.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  11. Review
  12. Towards the Prevention of Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026
    Review
  13. Observational
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Amy W AmaraDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kimberly H WoodDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Allen JoopDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Raima A MemonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jennifer PilkingtonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
S Craig TuggleUAB Center for Exercise Medicine. Birmingham, Alabama, USA.
John ReamsUAB Center for Exercise Medicine. Birmingham, Alabama, USA.
Matthew J BarrettDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
David A EdwardsDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Arthur L WeltmanDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Christopher P HurtUAB Center for Exercise Medicine. Birmingham, Alabama, USA.
Gary CutterUAB Center for Exercise Medicine. Birmingham, Alabama, USA.
Marcas M BammanDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USInstitute for Exercise and Environmental Medicine · USUniversity of Virginia · US

Funding

Rehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2019
$7.1M
Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8M
The essentiality of serine and glycine for skeletal muscle regeneration in agingR01AG075059 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THALACKER-MERCER, ANNA E. · 2022 to 2025
$1.5M
The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD PatientsK23NS080912 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMARA, AMY WILLIS · 2012 to 2016
$934k
National Center for Medical Rehabilitation Research P2CHD086851 National Rehabilitation Research ResouNIA NIH HHS R01 AG075059NICHD NIH HHS P2C HD086851NICHD NIH HHS T32 HD071866NINDS NIH HHS K23 NS080912NINDS NIH HHS K23NS080912Parkinson's Disease Foundation Translational Research GrantThe Curry FoundationThe Manning Foundation
6 · The paper itself

Abstract

backgroundSleep dysfunction is common and disabling in persons with Parkinson's Disease (PD). Exercise improves motor symptoms and subjective sleep quality in PD, but there are no published studies evaluating the impact of exercise on objective sleep outcomes. The goal of this study was to to determine if high-intensity exercise rehabilitation combining resistance training and body-weight interval training, compared with a sleep hygiene control improved objective sleep outcomes in PD.

methodsPersons with PD (Hoehn & Yahr stages 2-3; aged ≥45 years, not in a regular exercise program) were randomized to exercise (supervised 3 times a week for 16 weeks; n = 27) or a sleep hygiene, no-exercise control (in-person discussion and monthly phone calls; n = 28). Participants underwent polysomnography at baseline and post-intervention. Change in sleep efficiency was the primary outcome, measured from baseline to post-intervention. Intervention effects were evaluated with general linear models with measurement of group × time interaction. As secondary outcomes, we evaluated changes in other aspects of sleep architecture and compared the effects of acute and chronic training on objective sleep outcomes.

resultsThe exercise group showed significant improvement in sleep efficiency compared with the sleep hygiene group (group × time interaction: F = 16.0, P < 0.001, d = 1.08). Other parameters of sleep architecture also improved in exercise compared with sleep hygiene, including total sleep time, wake after sleep onset, and slow-wave sleep. Chronic but not acute exercise improved sleep efficiency compared with baseline.

conclusionsHigh-intensity exercise rehabilitation improves objective sleep outcomes in PD. Exercise is an effective nonpharmacological intervention to improve this disabling nonmotor symptom in PD. © 2020 International Parkinson and Movement Disorder Society.

Indexed as

Parkinson DiseaseSleep Wake DisordersAgedExercise TherapyGoalsHumansPolysomnographySleepTreatment OutcomeexerciseParkinson's diseasepolysomnographyrehabilitationsleep

Identifiers

PMID32092190
PMCPMC8826749
OpenAlexW3008026811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.