SynthesisBlood2020
Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis.
Synthesis in Blood, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Identifying risk factors for venous thromboembolism in medical inpatients: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.Health technology assessment (Winchester, England) · 2024Pooled it
- Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis.The Korean journal of internal medicine · 2024Pooled it
- Artificial intelligence in the prediction of venous thromboembolism: A systematic review and pooled analysis.European journal of haematology · 2023Pooled it
- Risk Factors for Anticoagulant-Associated Intracranial Hemorrhage: A Systematic Review and Meta-analysis.Neurocritical care · 2023Pooled it
- Risk factors for antiplatelet drug-associated intracranial hemorrhage: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Systematic review of venous thromboembolism risk categories derived from Caprini score.Journal of vascular surgery. Venous and lymphatic disorders · 2022Pooled it
- An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta-analysis.Journal of thrombosis and haemostasis : JTH · 2022Pooled it
- Risk Factors for Venous Thromboembolism in Severe COVID-19: A Study-Level Meta-Analysis of 21 Studies.International journal of environmental research and public health · 2021Pooled it
- Guideline
- Risk models for VTE and bleeding in medical inpatients: systematic identification and expert assessment.Blood advances · 2020Pooled it
- Article
- Prevalence and risk factors of symptomatic venous thromboembolism in distal femur fractures.Singapore medical journal · 2026Article
- Association Between Prolonged Immobilization and Venous Thromboembolism in Hospitalized Medical Patients.Cureus · 2026Article
- Venous thromboembolic and bleeding risk in population with obesity hospitalized for an acute medical illness receiving enoxaparin for thromboprophylaxis.Research and practice in thrombosis and haemostasis · 2026Article
- Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review.Journal of clinical medicine · 2026Article
- Venous thromboembolism in heart failure: incidence, phenotype-specific risk, and predictors in a large real-world cohort.Internal and emergency medicine · 2026Article
- Development and validation of risk models for hospital-acquired bleeding in medical inpatients: the Medical Inpatients Thrombosis and Hemostasis (MITH) study.Journal of thrombosis and haemostasis : JTH · 2026Article
- Development of Venous Thromboembolism Risk Prediction Models Based on Whole Blood Gene Expression Profiling Using 20 Machine Learning Algorithms: Comprehensive Analysis Study.JMIR medical informatics · 2026Article
- Development and validation of an interpretable machine learning model for venous thromboembolism risk prediction in patients with lung cancer: a real-world study.Frontiers in medicine · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There may be many predictors of venous thromboembolism (VTE) and bleeding in hospitalized medical patients, but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify prognostic factors for VTE and bleeding in hospitalized medical patients and searched Medline and EMBASE from inception through May 2018. We considered studies that identified potential prognostic factors for VTE and bleeding in hospitalized adult medical patients. Reviewers extracted data in duplicate and independently and assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. Of 69 410 citations, we included 17 studies in our analysis: 14 that reported on VTE, and 3 that reported on bleeding. For VTE, moderate-certainty evidence showed a probable association with older age; elevated C-reactive protein (CRP), D-dimer, and fibrinogen levels; tachycardia; thrombocytosis; leukocytosis; fever; leg edema; lower Barthel Index (BI) score; immobility; paresis; previous history of VTE; thrombophilia; malignancy; critical illness; and infections. For bleeding, moderate-certainty evidence showed a probable association with older age, sex, anemia, obesity, low hemoglobin, gastroduodenal ulcers, rehospitalization, critical illness, thrombocytopenia, blood dyscrasias, hepatic disease, renal failure, antithrombotic medication, and presence of a central venous catheter. Elevated CRP, a lower BI, a history of malignancy, and elevated heart rate are not included in most VTE risk assessment models. This study informs risk prediction in the management of hospitalized medical patients for VTE and bleeding; it also informs guidelines for VTE prevention and future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.