ArticlePloS one2020
Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs).
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Advances in vulvovaginal candidiasis research: a comprehensive review from epidemiology, diagnosis, treatment to resistance mechanisms.Frontiers in microbiology · 2026Review
- Advances in Antimicrobial Applications of Ag, Cu, and AgCu Nanoparticle-Doped Polymeric Composite Materials: A Comprehensive Review.ACS nano · 2025Review
- Antifungal potential of copper oxide nanoparticles againstCurrent medical mycology · 2025Article
- Antifungal activity of FeScientific reports · 2024Article
- Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to InhibitInternational journal of molecular sciences · 2024Article
- Development and characterization of biogenic copper oxide nanoparticles, with an exploration of their antibacterial and antioxidant potential.3 Biotech · 2024Article
- EnhancedCurrent medical mycology · 2023Article
- The Antimicrobial Applications of Nanoparticles in Veterinary Medicine: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2023Review
- Nude and Modified Electrospun Nanofibers, Application to Air Purification.Nanomaterials (Basel, Switzerland) · 2023Review
- Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.International journal of molecular sciences · 2022Review
- Poly-ε-Caprolactone-Hydroxyapatite-Alumina (PCL-HA-α-AlPolymers · 2022Article
- Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications.Materials (Basel, Switzerland) · 2022Review
- One step green synthesis of Cu nanoparticles by the aqueous extract of Juglans regia green husk: assessing its physicochemical, environmental and biological activities.Bioprocess and biosystems engineering · 2022Article
- Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity.PloS one · 2022Article
- Immunobiology and nanotherapeutics of severe acute respiratory syndrome 2 (SARS-CoV-2): a current update.Infectious diseases (London, England) · 2021Article
- Copper as an antimicrobial agent: recent advances.RSC advances · 2021Review
- Lichens-A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications.Journal of fungi (Basel, Switzerland) · 2021Review
- Current applications and prospects of nanoparticles for antifungal drug delivery.EXCLI journal · 2021Review
- Fabrication of aerosol-based nanoparticles and their applications in biomedical fields.Journal of pharmaceutical investigation · 2021Review
- Bursting the Virulence Traits of MDR Strain ofInternational journal of nanomedicine · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of metallic or ceramic nanoparticles in polymer matrices has improved the antimicrobial and antifungal behavior, resulting in the search for composites with increased bactericidal and antimycotic properties. A polycaprolactone fibers with copper oxide nanoparticles was prepared. Polycaprolactone-copper fibers (PCL- CuONPs) were prepared into two major steps in situ method: (a) Synthesis of CuO particles, then (b) incorporation of polycaprolactone to electrospun process. The first step is the reduction of Cu+2 ions by gallic acid in N,N-dimethylformamide and tetrahydrofuran solution with the simple addition of polycaprolactone in the solution for the second electrospun step. Raman spectra provide information about the nature of the copper oxide synthesized. There are three Raman peaks in the sample, at 294 and 581 cm-1 and a very broad band from 400 to 600 cm-1 which are characteristics bands for CuO. Scanning electron microscopy (TEM) revealed copper oxide nanoparticles with semispherical shapes with diameter 35 ±11 nm. Dynamic light scattering (DLS) analysis showed uniform CuONPs in a range of 88±11 nm. Scanning electron microscopy (SEM) of PCL-CuONps reveled fibers with diameters ranging from 925 to 1080 nm were successfully obtained by electrospinning technique. Orientation, morphology and diameter were influenced by the increment on CuONPs concentration, with the smaller diameter present in samples prepared from low concentrated solutions. The antimycotic applicability of the composite was evaluated to determine the antifungal activity in three species of the genus Candida (Candida albicans, Candida glabrata and Candida tropicalis). PCL-CuONPs exhibit a considerable antifungal effect on all species tested. The preparation of PCL-CuONPs was simple, fast and low-cost for practical application as an antifungal dressing.
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Registered trials
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