Evidence map›Paper›PMID 32091956›Full record

ArticleJournal of dental research2020

From Beyond the Pale to the Pale Riders: The Emerging Association of Bacteria with Oral Cancer.

Z R Fitzsimonds, C J Rodriguez-Hernandez, J Bagaitkar, R J Lamont

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies.International journal of environmental research and public health · 2021
    Pooled it
  2. Review
  3. Article
  4. Article
  5. From gut to mouth: salivary signatures of carcinogenic microbiota.Frontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Frontiers in cellular and infection microbiology · 2025
    Review
  16. Characterisation of novelJournal of oral microbiology · 2025
    Article
  17. Journal of oral microbiology · 2025
    Article
  18. The Oral Microbiome and Cancer.Advances in experimental medicine and biology · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Z R FitzsimondsDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-6523-4911
C J Rodriguez-HernandezDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA.
J BagaitkarDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA.
R J LamontDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-3147-5039
University of Louisville · US

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4M
MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Role of JAKs in innate responses to P. gingivalisR01DE017921 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2010 to 2019
$3.3M
Redox Regulation of Gingival InflammationR01DE028296 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2020 to 2024
$2.3M
Inflammation and Pathogenesis Training ProgramT32AI132146 · NIAID · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J, MITCHELL, THOMAS C. · 2018 to 2022
$640k
A novel role for NADPH oxidase in modulating neutrophil functions in periodontal diseaseR03DE028031 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2018 to 2019
$308k
Regulation of ZEB1 by Porphyromonas gingivalis in gingival epithelial cellsF30DE028166 · NIDCR · UNIVERSITY OF LOUISVILLE · PI FITZSIMONDS, ZACKARY R · 2018 to 2021
$150k
NIAID NIH HHS T32 AI132146NIDCR NIH HHS F30 DE028166NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE017921NIDCR NIH HHS R01 DE023193NIDCR NIH HHS R01 DE028296NIDCR NIH HHS R03 DE028031NIDCR NIH HHS R37 DE011111NIGMS NIH HHS P20 GM125504
6 · The paper itself

Abstract

Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is the eighth-most common cancer worldwide, with a 5-y survival rate <50%. There are numerous risk factors for oral cancer, among which periodontal disease is gaining increasing recognition. The creation of a sustained dysbiotic proinflammatory environment by periodontal bacteria may serve to functionally link periodontal disease and oral cancer. Moreover, traditional periodontal pathogens, such as

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsFusobacterium nucleatumHumansPorphyromonas gingivalisTumor MicroenvironmentF. nucleatumOSCCP. gingivalispolymicrobial synergy and dysbiosisS. gordoniiT. denticola

Identifiers

PMID32091956
PMCPMC7243420
OpenAlexW3007732895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.