SynthesisHaemophilia : the official journal of the World Federation of Hemophilia2020
The effect of resistance exercise on strength and safety outcome for people with haemophilia: A systematic review.
Synthesis in Haemophilia : the official journal of the World Federation of Hemophilia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Exercise Training on Pain, Physical Activity and Quality of Life in Pediatric Hemophilia Patients
The Validity and Reliability of the Turkish Version of the "Pediatric Haemophilia Activities List - Short - PedHALshort" Questionnaire
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of physical exercise on postural balance in patients with haemophilia: A systematic review.Haemophilia : the official journal of the World Federation of Hemophilia · 2022Pooled it
- The effect of resistance exercise on strength and safety outcome for people with haemophilia: A systematic review.Haemophilia : the official journal of the World Federation of Hemophilia · 2020Pooled it
- Effectiveness of progressive moderate-vigorous intensity elastic resistance training on quality of life and perceived functional abilities in people with hemophilia: Secondary analysis of a randomized controlled trial.European journal of haematology · 2023Trial
- Low-Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial.Haemophilia : the official journal of the World Federation of HemophiliaTrial
- Association of musculoskeletal impairments and balance with quality of life in adults with severe hemophilia A: a cross-sectional study.BMC musculoskeletal disorders · 2026Observational
- Hemophilia in the Era of Advanced Therapies: Structural Monitoring, the Role of Musculoskeletal Ultrasound, and a Proposed Multidisciplinary Care Model-A Structured Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- The relationship between joint health, kinesiophobia, physical activity level, and functional capacity in hemophilia patients: a case-control study.Acta orthopaedica et traumatologica turcica · 2026Article
- Managing Haemophilic Arthropathy in People With Haemophilia in Japan: An Informal Consensus.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- The Role of Postural Assessment, Therapeutic Exercise and Foot Orthoses in Haemophilic Arthropathy: A Pilot Study.Life (Basel, Switzerland) · 2025Article
- Hemophilic Arthropathy of the Knee and Its Association with Reduced Muscle Strength and Activation and the Pressure Pain Threshold: A Case-Control Study.Journal of clinical medicine · 2023Article
- The evolution of physiotherapy in the multidisciplinary management of persons with haemophilia (PWH): A scoping review.Haemophilia : the official journal of the World Federation of Hemophilia · 2023Article
- Promoting physical activity in people with haemophilia: the MEMO (Movement for persons with haEMOphilia) expert consensus project.Blood transfusion = Trasfusione del sangue · 2022Article
- Project GYM: A randomized feasibility study investigating effect on motivation of personal trainer-led exercise in young men with hemophilia.Research and practice in thrombosis and haemostasis · 2021Article
- EMG, Rate of Perceived Exertion, Pain, Tolerability and Possible Adverse Effects of a Knee Extensor Exercise with Progressive Elastic Resistance in Patients with Severe Haemophilia.Journal of clinical medicine · 2020Article
- Establishing an online physical exercise program for people with hemophilia.Wiener klinische Wochenschrift · 2019Article
- Exercise Programmes for People With Haemophilia: A Scoping Review.Haemophilia : the official journal of the World Federation of HemophiliaArticle
- A systematic review of psychometric properties of physical fitness and physical functioning outcome measures applied in adult people with hemophilia.Archives of physiotherapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHaemophilia is a congenital bleeding disorder with severe musculoskeletal complications. Resistance exercise is important to increase joint stability and to improve physical performance.
aimThis review aimed to investigate the safety and efficacy of resistance exercise interventions on people with haemophilia (PwH) and evaluate whether the American College of Sports Medicine resistance exercise criteria for healthy adults are valid for this population.
methodsA systematic search in literature was conducted, using the databases PubMed, MEDLiNE, CINAHL, SCOPUS, PEDro and Cochrane Library. Out of 2.440 studies published between 1960 and November 2019, 14 studies (9 randomized controlled trials, 1 controlled trial, 4 single-group prospective studies) applying resistance exercise in juvenile and adult PwH corresponded to the inclusion criteria.
resultsStudies performed dynamic, isokinetic or a combination of isometric and dynamic resistance training. Most interventions were carried out in the context of a multimodal training. Resistance was provided using fixed and free weights, body weight, resistance bands and water resistance. Study protocols included clinical and home-based settings. Several studies suggest that training intensities lower than those known to increase the strength of healthy people are effective in increasing the strength of PwH. Resistance exercise seems to be a safe intervention if it is adequately monitored, individually adapted and applied with sufficient factor therapy. Due to the heterogeneity of study designs, training interventions and outcome measures a meta-analysis could not be performed.
conclusionsFurther studies of higher methodological quality are needed to determine the optimal types of exercise, optimal dosage and timing.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.