Evidence map›Paper›PMID 32091369›Full record

ArticleEmerging infectious diseases2020

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.

Matthias Merker, Elena Nikolaevskaya, Thomas A Kohl, Barbara Molina-Moya, Olha Pavlovska, Patrik Brännberg, Andrii Dudnyk, Valentyna Stokich, Ivan Barilar, Iryna Marynova and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Use of reverse dot blot hybridization DNA-array and targeted next-generation sequencing for the detection of drug resistance in patients with tuberculosis: a prospective diagnostic accuracy study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Review
  5. Article
  6. Frontiers in microbiology · 2026
    Article
  7. Article
  8. Article
  9. Drug-Resistant Profiles and Genetic Diversity ofInfection and drug resistance · 2024
    Article
  10. Article
  11. Review
  12. Prevalence ofJournal of clinical tuberculosis and other mycobacterial diseases · 2023
    Article
  13. Review
  14. Phylogenetic relationships ofFrontiers in cellular and infection microbiology · 2023
    Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.Journal of clinical tuberculosis and other mycobacterial diseases · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 4 countries.

Matthias Merker
Elena Nikolaevskaya
Thomas A Kohl
Barbara Molina-Moya
Olha Pavlovska
Patrik Brännberg
Andrii Dudnyk
Valentyna Stokich
Ivan Barilar
Iryna Marynova
Tetiana Filipova
Cristina Prat
Anders Sjöstedt
Jose Dominguez
Olena Rzhepishevska
Stefan Niemann
German Center for Infection Research · DENational Pirogov Memorial Medical University, Vinnytsya · UACentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESUniversitat Autònoma de Barcelona · ESCentro de Investigación Biomédica en Red de Cáncer · ESOdesa I. I. Mechnikov National University · UAResearch Center Borstel - Leibniz Lung Center · DEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

Indexed as

AdultAntitubercular AgentsContact TracingDrug Resistance, Multiple, BacterialExtensively Drug-Resistant TuberculosisFemaleHumansMaleMiddle AgedMycobacterium tuberculosisTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryUkraineUrban PopulationAntitubercular Agentsantimicrobial resistanceBeijing lineagecontact tracingdrug resistanceMDR TBMycobacterium tuberculosistuberculosistuberculosis and other mycobacteriaUkrainewhole-genome sequencingXDR TB

Identifiers

PMID32091369
PMCPMC7045844
OpenAlexW3004998793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.