ArticleJournal of clinical laboratory analysis2020
ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five-center case-control study.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Functional Role of ALKBH5 in Kidney Injury: Insights Into Mechanisms and Therapeutic Potential.Journal of cellular biochemistry · 2026Review
- ALKBH1 Gene rs6494 T>A Polymorphism Decreases Wilms Tumour Risk in Chinese Children.Journal of cellular and molecular medicine · 2025Article
- Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort.Cancers · 2025Article
- Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study.BMC cancer · 2025Article
- Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children.BMC cancer · 2025Article
- NJournal of experimental & clinical cancer research : CR · 2024Article
- LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study.BMC cancer · 2024Article
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- Article
- Identification of the expression patterns and potential prognostic role of m6A-RNA methylation regulators in Wilms Tumor.BMC medical genomics · 2023Article
- Article
- Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis.Frontiers in cellular and infection microbiology · 2022Article
- Article
- METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children.BMC cancer · 2021Article
- Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (mBioengineered · 2021Article
- Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five-center case-control study.Journal of clinical laboratory analysis · 2021Article
- Article
- The Genetic Changes of Hepatoblastoma.Frontiers in oncology · 2021Review
- The contribution ofJournal of Cancer · 2021Article
- ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five-center case-control study.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundWilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6-methyladenosine (m
methodsHerein, we evaluated the association of single nucleotide polymorphisms (SNPs) in the m
resultsNo significant association was detected between these two polymorphisms and Wilms tumor risk. Moreover, 1, 2, and 1-2 protective genotypes (rs1378602 AG/AA or rs8400 GG) did not significantly reduce Wilms tumor risk, compared with risk genotypes only. Stratification analysis revealed a significant relationship between rs1378602 AG/AA genotypes and decreased Wilms tumor risk in children in clinical stage I diseases [adjusted odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.32-0.98, P = .042]. The presence of 1-2 protective genotypes was correlated with decreased Wilms tumor risk in subgroups of age > 18 months, when compared to the absence of protective genotypes (adjusted OR = 0.74, 95% CI = 0.56-0.98, P = .035).
conclusionCollectively, our results demonstrate that ALKBH5 SNPs may exert a weak influence on susceptibility to Wilms tumor. This finding increases the understanding of the role of the m
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