ArticleJournal of affective disorders2020
Neuroanatomical predictors of L-DOPA response in older adults with psychomotor slowing and depression: A pilot study.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.Brain : a journal of neurology · 2026Review
- Neural Mechanisms of Age-Related Loss of Muscle Performance and Physical Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Is impaired dopaminergic function associated with mobility capacity in older adults?GeroScience · 2021Article
Corrections and comments
- Retraction · 2023-03-23Error in Analyses · Error in Data · Falsification/Fabrication of Data · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Unreliable Results and/or Conclusions · · see also: https://www.thetransmitter.org/retraction/flawed-protocol-for-levodopa-clinical-trial-brings-retractions/; bret R Rutherford has ORI finding of misconduct, see: https://ori.hhs.gov/content/case-summary-rutherford-bret;
- Commented on by
- Retracted
Authors and funding
11 authors.
Funding
Abstract
backgroundDeclining function in dopamine circuits is implicated in normal aging and late-life depression (LLD). Dopamine augmentation recently has shown therapeutic promise, but predictors of response are unknown.
methodsDepressed elders with slowed gait underwent baseline magnetic resonance imaging (MRI) and [
resultsAmong N = 16 participants aged 72.5 ± 6.8 years, higher left superior temporal gyrus volume was associated with higher processing speed at baseline, while cortical thinning in a processing speed network was associated with greater improvement following L-DOPA. Greater volume and cortical thickness in brain regions associated with mobility were associated with higher baseline gait speed. Higher baseline white matter hyperintensity volume predicted less post-L-DOPA improvement on dual task gait speed and IDS-SR scores. Higher [ LIMITATIONS: Limiting the conclusions drawn from this pilot study are the small sample size and open administration of L-DOPA.
conclusionsGreater baseline brain volumes and cortical thickness in regions supporting cognition and gait were associated with higher behavioral performance, while lower structural integrity was associated with increased responsivity to L-DOPA. If substantiated in larger studies, these findings could facilitate the targeting of dopaminergic treatments to those LLD patients most likely to respond.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.