Evidence map›Paper›PMID 32090696›Full record

ArticleNeurocase2020

Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity.

Andy J Liu, Jessica E Chang, Georges Naasan, Adam L Boxer, Bruce L Miller, Salvatore Spina

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neurocase, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Comorbid pathologies and their impact on progressive supranuclear palsy: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Article
  3. Primary Lateral Sclerosis: An Overview.Journal of clinical medicine · 2024
    Review
  4. Article
  5. Article
  6. Clinical Spectrum of Tauopathies.Frontiers in neurology · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andy J LiuMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Jessica E ChangDepartment of Psychological Services, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Georges NaasanMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Adam L BoxerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Salvatore SpinaMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity Memory and Aging Center · USSan Francisco VA Medical Center · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
Neuropathological basis of brain network dysfunctionK08AG052648 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINA, SALVATORE · 2016 to 2020
$852k
NIA NIH HHS K08 AG052648NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG048234NIA NIH HHS T32 AG023481
6 · The paper itself

Abstract

Globular glial tauopathy (GGT) is a rare 4-repeat tauopathy characterized by the accumulation of tau globular inclusions in astrocytes and oligodendrocytes. Several clinical phenotypes have been associated with GGT, making the prediction of this rare pathological entity difficult. We report the case of a patient with eye-movement abnormalities and gait instability, reminiscent of progressive supranuclear palsy-Richardson's syndrome (PSP-RS), who later developed upper motor neuron symptoms suggestive of primary lateral sclerosis (PLS). Neuropathological assessment revealed GGT type III pathology. A theoretical framework is proposed to help clinicians predict GGT in subjects with coexistent features of PSP-RS and PLS.

Indexed as

Aged, 80 and overFatal OutcomeFrontotemporal DementiaGait Disorders, NeurologicHumansMaleMotor Neuron DiseaseNeurogliaOcular Motility DisordersSupranuclear Palsy, ProgressiveTauopathiesfrontotemporal dementiaGlobular glial tauopathyneuropathologyprimary lateral sclerosisprogressive supranuclear palsy

Identifiers

PMID32090696
PMCPMC7197509
OpenAlexW3006853477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.