Evidence map›Paper›PMID 32090604›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.

Krishnan MohanKumar, Kopperuncholan Namachivayam, Nithya Sivakumar, Natascha G Alves, Venkataramana Sidhaye, Jayanta K Das, Yerin Chung, Jerome W Breslin, Akhil Maheshwari

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders.Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2024
    Review
  9. Review
  10. Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  11. Review
  12. Article
  13. Biology of Anemia: A Public Health Perspective.The Journal of nutrition · 2023
    Article
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Krishnan MohanKumarDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Kopperuncholan NamachivayamDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Nithya SivakumarDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Natascha G AlvesDepartment of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida.
Venkataramana SidhayeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jayanta K DasDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Yerin ChungDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jerome W BreslinDepartment of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0003-4867-3151
Akhil MaheshwariDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Johns Hopkins University · USUniversity of South Florida · US

Funding

Role of E-cadherin in modulating airway epithelial function and parenchymal remodelingR01HL151107 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2020 to 2023
$2.4M
Actin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL124078NHLBI NIH HHS R01 HL124099NHLBI NIH HHS R01 HL151107
6 · The paper itself

Abstract

Anemia is a frequent diagnosis in critically ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined preweaned mice to investigate the effects of severe anemia during early infancy on gut mucosal permeability. C57BL/6 mice were subjected to timed phlebotomy between

Indexed as

Adherens JunctionsAnemia, NeonatalAnimalsAnimals, NewbornCaco-2 CellsCadherinsFemaleGene Expression RegulationHumansIntestinal MucosaIntestinesMaleMiceMicroRNAsPermeabilityRNA, MessengerCadherinsCdh1 protein, mouseMicroRNAsmirnlet7e microRNA, mouseRNA, MessengerbarriercytoskeletonmicroRNAtranslocationtubulin

Identifiers

PMID32090604
PMCPMC7191465
OpenAlexW3008259546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.