Evidence map›Paper›PMID 32090602›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Signaling through the interleukin-4 and interleukin-13 receptor complexes regulates cholangiocyte TMEM16A expression and biliary secretion.

Amal K Dutta, Kristy Boggs, Al-Karim Khimji, Yonas Getachew, Youxue Wang, Charles Kresge, Don C Rockey, Andrew P Feranchak

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The role of anoctamin 1 in liver disease.Journal of cellular and molecular medicine · 2024
    Review
  6. Article
  7. Article
  8. The diverse roles of TMEM16A CaJournal of advanced research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amal K DuttaDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Kristy BoggsDepartment of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Al-Karim KhimjiDepartment of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Yonas GetachewDepartment of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Youxue WangDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Charles KresgeDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Don C RockeyDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Andrew P FeranchakDepartment of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
The University of Texas Southwestern Medical Center · USUniversity of Pittsburgh Medical Center · USMedical University of South Carolina · US

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Mechanosensitive Signaling and Cholangiocyte SecretionR01DK078587 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI FERANCHAK, ANDREW P · 2008 to 2019
$3.6M
A Molecular Approach to the Pathogenesis of Portal HypertensionR01DK113159 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2017 to 2026
$2.7M
The Cell and Molecular Biology of Myofibroblasts in Hepatic FibrosisR01DK098819 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROCKEY, DON C. · 2014 to 2017
$1.3M
NIDDK NIH HHS P30 DK120531NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK078587NIDDK NIH HHS R01 DK098819NIDDK NIH HHS R01 DK113159
6 · The paper itself

Abstract

TMEM16A is a Ca

Indexed as

Adenosine TriphosphateAnimalsAnoctamin-1Bile Acids and SaltsBile DuctsCell LineChloridesElectrophysiological PhenomenaGene Expression RegulationHumansJanus Kinase 3LiverMaleMicePatch-Clamp TechniquesRatsAdenosine TriphosphateAnoctamin-1Bile Acids and SaltsChloridesJanus Kinase 3Receptors, Interleukin-13Receptors, Interleukin-4STAT6 Transcription Factorbile formationbiliary epitheliumcalcium-activated chloride channelsinterleukin-13interleukin-4Janus kinasesignal transducer and activator of transcription 6

Identifiers

PMID32090602
PMCPMC7191463
OpenAlexW3007561288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.