ArticleObesity (Silver Spring, Md.)2020
Thirty-Year Risk of Cardiovascular Disease Events in Adolescents with Severe Obesity.
Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00474318 (Teen-Longitudinal Assessment of Bariatric Surgery), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of surgical versus medical therapy on estimated cardiovascular event risk among adolescents with type 2 diabetes and severe obesity.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021 · on this mapTrial
- Metabolic dysfunction-associated steatotic liver disease-a review of the cardiometabolic perspectives and treatments in children.International journal of obesity (2005) · 2026Review
- Appetitive traits and long-term risk of disordered eating: a 3-year follow-up in children with overweight and obesity.Eating and weight disorders : EWD · 2026Article
- The global burden of cardiovascular diseases attributable to high body mass index, 1990-2023.Frontiers in cardiovascular medicine · 2026Article
- Examining effects of sleeve gastrectomy in an urban youth population.Obesity pillars · 2025Article
- A Clinical Tool to Relate Youth Risk Factors to Adult Cardiovascular Events and Type 2 Diabetes: The International Childhood Cardiovascular Cohort Consortium.The Journal of pediatrics · 2025Observational
- Association of Weight Change Across Adulthood with Obstructive Sleep Apnea: The Multi-Ethnic Study of Atherosclerosis.Nature and science of sleep · 2025Article
- Early adulthood BMI and cardiovascular disease: a prospective cohort study from the China Kadoorie Biobank.The Lancet. Public health · 2024Article
- The age of the obesity onset is a very important factor for the development of metabolic complications and cardiovascular risk in children and adolescents with severe obesity.European journal of pediatrics · 2024Article
- Bone mineral density in young adults 5 to 11 years after adolescent metabolic and bariatric surgery for severe obesity compared to peers.International journal of obesity (2005) · 2024Article
- Changes in body weight and cardiovascular risk factors in a Chinese population with type 2 diabetes mellitus: a longitudinal study.Frontiers in endocrinology · 2023Article
- Benefits of Physical Activity on Cardiometabolic Diseases in Obese Children and Adolescents.Journal of translational internal medicine · 2022Article
- Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort.Diagnostics (Basel, Switzerland) · 2022Article
- Metabolic and hormonal changes after laparoscopic sleeve gastrectomy in pediatric population: An observational study.Frontiers in surgery · 2022Article
- Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease.International journal of obesity (2005) · 2021Review
- Update on Metabolic Bariatric Surgery for Morbidly Obese Adolescents.Children (Basel, Switzerland) · 2021Review
- Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States.Expert review of endocrinology & metabolism · 2021Article
- Lipid Inhibitory Effect of (-)-loliolide Isolated fromMarine drugs · 2021Article
- Lipid metabolism is altered in maternal, placental, and fetal tissues of ewes with small for gestational age fetuses†.Biology of reproduction · 2021Article
- Impact of Pediatric Obesity on Diurnal Blood Pressure Assessment and Cardiovascular Risk Markers.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveQuantifying risk for cardiovascular disease (CVD) events among adolescents is difficult owing to the long latent period between risk factor development and disease outcomes. This study examined the 30-year CVD event risk among adolescents with severe obesity treated with and without metabolic and bariatric surgery (MBS), compared with youths with moderate obesity, overweight, or normal weight.
methodsCross-sectional and longitudinal comparisons of five frequency-matched (age and diabetes status) groups were performed: normal weight (n = 247), overweight (n = 54), obesity (n = 131), severe obesity without MBS (n = 302), and severe obesity undergoing MBS (n = 215). A 30-year CVD event score developed by the Framingham Heart Study was the primary outcome. Data are mean (SD) with differences between time points for MBS examined using linear mixed models.
resultsPreoperatively, the likelihood of CVD events was higher among adolescents undergoing MBS (7.9% [6.7%]) compared with adolescents with severe obesity not referred for MBS (5.5% [4.0%]), obesity (3.9% [3.0%]), overweight (3.1% [2.4%]), and normal weight (1.8% [0.8%]; all P < 0.001). At 1 year after MBS, event risk was significantly reduced (7.9% [6.7%] to 4.0% [3.4%], P < 0.0001) and was sustained for up to 5 years after MBS (P < 0.0001, all years vs. baseline).
conclusionsAdolescents with severe obesity are at elevated risk for future CVD events. Following MBS, the predicted risk of CVD events was substantially and sustainably reduced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.