ArticleMolecular systems biology2020
Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.
Article in Molecular systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration.Nature communications · 2026Article
- Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026Article
- Simulation-based inference of cell migration dynamics in complex spatial environments.NPJ systems biology and applications · 2026Article
- Mechanochemical patterning localizes the organizer of a luminal epithelium.Science advances · 2025Article
- Lineage plasticity and reprogramming of epithelial cells during tissue injury and regeneration-lessons from the lineage plasticity of hepatocytes and cholangiocytes induced by liver injury.Regenerative therapy · 2025Review
- Hepatocyte differentiation requires anisotropic expansion of bile canaliculi.Development (Cambridge, England) · 2024Article
- Article
- The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4Aging and disease · 2024Article
- A wall-time minimizing parallelization strategy for approximate Bayesian computation.PloS one · 2024Article
- FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes.Bioinformatics (Oxford, England) · 2023Article
- Bile Acid Overload Induced by Bile Duct and Portal Vein Ligation Improves Survival after Staged Hepatectomy in Rats.Current medical science · 2023Article
- Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease.EMBO reports · 2023Article
- Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure.The Journal of cell biology · 2023Article
- Article
- Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy.iScience · 2023Article
- Role of the Hippo pathway in liver regeneration and repair: recent advances.Inflammation and regeneration · 2022Review
- Role of YAP1 Signaling in Biliary Development, Repair, and Disease.Seminars in liver disease · 2022Review
- Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.The Journal of cell biology · 2021Article
- Determination by Relaxation Tests of the Mechanical Properties of Soft Polyacrylamide Gels Made for Mechanobiology Studies.Polymers · 2021Article
- Gallbladder fossa volume decreased in livers without gallbladders: A cadaveric study.PloS one · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of organ size control remain poorly understood. A key question is how cells collectively sense the overall status of a tissue. We addressed this problem focusing on mouse liver regeneration. Using digital tissue reconstruction and quantitative image analysis, we found that the apical surface of hepatocytes forming the bile canalicular network expands concomitant with an increase in F-actin and phospho-myosin, to compensate an overload of bile acids. These changes are sensed by the Hippo transcriptional co-activator YAP, which localizes to apical F-actin-rich regions and translocates to the nucleus in dependence of the integrity of the actin cytoskeleton. This mechanism tolerates moderate bile acid fluctuations under tissue homeostasis, but activates YAP in response to sustained bile acid overload. Using an integrated biophysical-biochemical model of bile pressure and Hippo signaling, we explained this behavior by the existence of a mechano-sensory mechanism that activates YAP in a switch-like manner. We propose that the apical surface of hepatocytes acts as a self-regulatory mechano-sensory system that responds to critical levels of bile acids as readout of tissue status.
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