ArticleMolecular genetics & genomic medicine2020
Waist circumference increases risk of coronary heart disease: Evidence from a Mendelian randomization study.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- A Bayesian network model of new-onset diabetes in older Chinese: The Guangzhou biobank cohort study.Frontiers in endocrinology · 2022Trial
- Higher Dietary Antioxidant Index Is Associated with Better Lipid Profile in Women with Coronary Artery Disease.Healthcare (Basel, Switzerland) · 2026Article
- Association Between Waist Circumference and Coronary Artery Disease: Evidence from the NHANES 1999-2023 Cross-Sectional Data and Mendelian Randomization Analysis.Global heart · 2026Article
- Article
- Association between childhood adiposity and gynecologic cancers: a mendelian randomization analysis.BMC women's health · 2025Article
- Which adiposity marker is most strongly associated with all‑cause and cause‑specific mortality? a prospective study of 158,699 Mexican adults.International journal of obesity (2005) · 2025Article
- Metabolic health in the Slovenian national cohort of kidney transplant patients.Clinical nephrology · 2025Article
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- The Relationship of Waist Circumference with the Morbidity of Cardiovascular Diseases and All-Cause Mortality in Metabolically Healthy Individuals: A Population-Based Cohort Study.Reviews in cardiovascular medicine · 2024Article
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- Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study.Clinical and experimental gastroenterology · 2024Article
- Ratio of waist circumference to body mass index: A novel predictor of clinical outcome in hypertension patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Federated machine learning for a facilitated implementation of Artificial Intelligence in healthcare - a proof of concept study for the prediction of coronary artery calcification scores.Journal of integrative bioinformatics · 2022Article
- High waist circumference is a risk factor of new-onset hypertension: Evidence from the China Health and Retirement Longitudinal Study.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Development and Validation of a Prognostic Model to Predict High-Risk Patients for Coronary Heart Disease in Snorers With Uncontrolled Hypertension.Frontiers in cardiovascular medicine · 2022Article
- Analysis of Blood Pressure and Ventilation Efficiency in Different Types of Obesity Aged 40-60 Years by Cardiopulmonary Exercise Test.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Development and Validation of a Coronary Heart Disease Risk Prediction Model in Snorers with Hypertension: A Retrospective Observed Study.Risk management and healthcare policy · 2022Article
- Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction.Scientific reports · 2021Article
- The Association of Waist Circumference and the Risk of Deep Vein Thrombosis.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated whether expanding waist circumference (WC) is causally associated with an elevated risk of coronary heart disease (CHD), using a two-sample Mendelian randomization (MR) study through integrating summarized data from genome-wide association study.
methodsThe data included in this analysis were mainly from the Genetic Investigation of ANthropometric Traits (GIANT), Consortium and Coronary Artery Disease Genome wide Replication, and Meta-analysis plus the Coronary Artery Disease (C4D) Genetics (CARDIoGRAMplusC4D) Consortium. Three statistical approaches, inverse-variance weighted (IVW), weighted median, and MR-Egger regression method were conducted to assess the casual relationship. The exposure was WC, measured by 46 single-nucleotide polymorphisms from GIANT and the outcome was the risk of CHD. Then, we used the genetic data from Neale Lab and TAG to infer whether WC causally affected the established risk factors of CHD.
resultsThe IVW method presented that genetically predicted WC was positively casually associated with CHD (odds ratio [OR]: 1.57, 95% CI = 1.33-1.84; p = 4.81e-08), which was consistent with the result of weighted median and MR-Egger regression. MR-Egger regression indicated that there was no directional horizontal pleiotropy to violate the MR assumption. Additionally, expanded WC was also associated with higher risk of hypertension and diabetes, higher cholesterol, more smoking intensity, and decreased frequency of physical activity.
conclusionOur analysis provided strong evidence to indicate a causal relationship between WC and increased risk of CHD.
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