ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020
Impact of deceased donor multidrug-resistant bacterial organisms on organ utilization.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The species, distribution, resistance of donor-derived pathogens and their impact on solid organ transplant recipients.Frontiers in immunology · 2026Article
- Can We Lower the Burden of Antimicrobial Resistance (AMR) in Heavily Immunocompromised Patients? A Narrative Review and Call to Action.Infectious diseases and therapy · 2025Review
- ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus.The Lancet regional health. Southeast Asia · 2025Review
- Preemptive antibiotic strategies for gram-positive bacteria in preservation fluid: a single-center experience.Frontiers in medicine · 2025Article
- Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Epidemiology and Prevention of Early Infections by Multi-Drug-Resistant Organisms in Adults Undergoing Liver Transplant: A Narrative Review.Microorganisms · 2023Review
- Optimal Perioperative Antimicrobial Management Strategies of Kidney Transplant Recipients Guided by Metagenomic Next-Generation Sequencing of Deceased Donors' Microbiology Samples.Infection and drug resistance · 2023Article
- Establishment of a risk prediction model for multidrug-resistant bacteria in deceased organ donors: a retrospective cohort study in China.Frontiers in cellular and infection microbiology · 2023Article
- Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- Challenges of Antimicrobial Resistance and Stewardship in Solid Organ Transplant Patients.Current infectious disease reports · 2022Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
The extent to which donor multidrug-resistant organisms (MDROs) affect organ utilization remains unclear. We performed a retrospective cohort study at 4 transplant centers between 2015 and 2016 to evaluate this question. All deceased donors who donated at least one organ were included. Exposed donors had at least one MDRO on culture. Unexposed donors had no MDRO-positive cultures. Only cultures obtained during the donor's terminal hospitalization were evaluated. Multivariable regression was used to determine the association between donor MDRO and (1) number of organs transplanted per donor and (2) the match run at which each organ was accepted. Subsequently, we restricted the analysis to donors with MDR-Gram-negative (GN) organisms. Of 440 total donors, 29 (7%) donors grew MDROs and 7 (2%) grew MDR-GNs. There was no significant association between donor MDRO and either measure of organ utilization. However, donor MDR-GNs were associated with a significant reduction in the number of organs transplanted per donor (incidence rate ratio 0.43, 95% confidence interval [CI] 0.39-0.48, P < .01), and organs were accepted significantly further down the match list (relative count 5.08, 95% CI 1.64-15.68, P = .01). Though donor MDR-GNs were infrequent in our study, their growing prevalence could meaningfully reduce the donor pool over time.
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