Evidence map›Paper›PMID 32090359›Full record

ReviewThe EMBO journal2020

A guide to naming human non-coding RNA genes.

Ruth L Seal, Ling-Ling Chen, Sam Griffiths-Jones, Todd M Lowe, Michael B Mathews, Dawn O'Reilly, Andrew J Pierce, Peter F Stadler, Igor Ulitsky, Sandra L Wolin and 1 more

Abstract readReview
In one paragraph

Review in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The diploid reference genome of a human embryonic stem cell line.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Glucocorticoids regulate the human non-coding genome.bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Genome biology of long non-coding RNAs in humans: A virtual karyotype.Computational and structural biotechnology journal · 2025
    Article
  15. Article
  16. The role of super-enhancer-driven lncRNAs in cancer.Computational and structural biotechnology journal · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Therapeutic and diagnostic applications of exosomes in colorectal cancer.Medical oncology (Northwood, London, England) · 2024
    Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruth L SealDepartment of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID 0000-0002-7545-6817
Ling-Ling ChenState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai, China.
Sam Griffiths-JonesSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Todd M LoweDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.
Michael B MathewsDepartment of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Dawn O'ReillyComputational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.
Andrew J PierceTranslational Medicine, Oncology R&D, AstraZeneca, Cambridge, UK.
Peter F StadlerBioinformatics Group, Department of Computer Science, Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.
Igor UlitskyDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-0555-6561
Sandra L WolinRNA Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Elspeth A BrufordDepartment of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Funding

Biogenesis, Function and Turnover of Noncoding RNAsZIABC011757 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOLIN, SANDRA · 2017 to 2025
$20.4M
A Unified Atlas of Dynamic tRNA FunctionR01HG006753 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOWE, TODD MICHAEL · 2012 to 2022
$4.6M
The Nomenclature of Human and Vertebrate GenesU24HG003345 · NHGRI · UNIVERSITY OF CAMBRIDGE · PI Elspeth Bruford · 2018 to 2026
$3.9M
NHGRI NIH HHS R01 HG006753NHGRI NIH HHS U24 HG003345Wellcome TrustWellcome Trust (WT) 208349/Z/17/Z
6 · The paper itself

Abstract

Research on non-coding RNA (ncRNA) is a rapidly expanding field. Providing an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as it allows unambiguous communication about each gene. The HUGO Gene Nomenclature Committee (HGNC, www.genenames.org) is the only group with the authority to approve symbols for human genes. The HGNC works with specialist advisors for different classes of ncRNA to ensure that ncRNA nomenclature is accurate and informative, where possible. Here, we review each major class of ncRNA that is currently annotated in the human genome and describe how each class is assigned a standardised nomenclature.

Indexed as

Terminology as TopicGenome, HumanHumansRNA, UntranslatedRNA, Untranslatedgene nomenclaturegene symbolsnon-coding RNA

Identifiers

PMID32090359
PMCPMC7073466

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.