Evidence map›Paper›PMID 32090282›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020

A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan.

Yu-Mei Kang, Shih-Chieh Lin, Yi-Yen Lee, Feng-Chi Chang, Muh-Lii Liang, Hsin-Hung Chen, Tai-Tong Wong, Yi-Wei Chen

Abstract read
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. [Clinical analysis of 30 cases of basal ganglia germinoma in children].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yu-Mei KangFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Shih-Chieh LinFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yi-Yen LeeFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Feng-Chi ChangFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Muh-Lii LiangFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Hsin-Hung ChenFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Tai-Tong WongFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yi-Wei ChenFaculty of Medicine, National Yang-Ming University, Taipei, Taiwan. chenyw@vghtpe.gov.tw.ORCID 0000-0003-3946-7540
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA basal ganglia (BG) germinoma is a rare tumor, and the optimal treatment remains unknown. We evaluated the clinical outcomes of treatment of BG germinoma in pediatric patients in Taiwan.

methodsWe retrospectively reviewed the medical records of 34 children with BG germinoma who were treated with radiotherapy (RT) at Taipei Veterans General Hospital between 1989 and 2016. The median follow-up time is 8.3 years (1.8-25.2 years). Survival was analyzed using the Kaplan-Meier estimate. Univariate Cox proportional-hazards models were used to identify the potential risk factors.

resultsOnly four patients (11.8%) experienced recurrence and all successfully underwent salvage therapy. One patient (2.97%) died due to suspected radiotherapy (RT)-related sarcoma in the scalp. The 2-, 3-, and 5-year DFS rates were 91.2%, 88.2%, and 79.4%, respectively; the 2-, 3-, and 5-year OS rates were 97.1%, 94.1%, and 82.4%, respectively. Focal RT showed low DFS in the Kaplan-Meier survival curves (P = .028) compared with non-focal RT (whole ventricle, whole brain, or cranial spinal area). In the univariate Cox proportional-hazards model, there was a significant difference in DFS between focal and non-focal RT (P = .03). There is no difference in DFS and OS between BG germinoma patients and non-BG germinoma patients.

conclusionsWe found an excellent DFS and OS in pediatric patients with BG germinoma treated with RT. Whole ventricle irradiation is recommended for good tumor control and low treatment-related toxicity. BG germinoma patients showed similar treatment results as germinoma patients in other common sites.

Indexed as

Brain NeoplasmsGerminomaBasal GangliaChildHumansNeoplasm Recurrence, LocalRadiotherapy DosageRetrospective StudiesTaiwanTreatment OutcomeBasal gangliaChemotherapyGerminomaPediatricRadiotherapyWhole ventricular irradiation

Identifiers

PMID32090282
OpenAlexW3007999848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.