ArticleSchizophrenia bulletin2020
Psychotic Experiences in Schizophrenia and Sensitivity to Sensory Evidence.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Altered semantic prediction error processing with increasing schizotypal and autistic traits.Translational psychiatry · 2026Article
- Predictive Inference Alterations in Psychosis Proneness Show Task-Dependent Signatures.Annals of the New York Academy of Sciences · 2026Article
- Preserved contextual modulation of eye movements in psychosis prone individuals.Journal of vision · 2026Article
- Social priors and mentalizing connectivity across autistic and schizotypal traits.Social cognitive and affective neuroscience · 2026Article
- Article
- Reduced weighting of short-term perceptual priors during auditory perceptual decision-making in psychosis-prone individuals.BMC biology · 2025Article
- Temporal stability of semantic predictions in subclinical autistic and schizotypal personality traits.Schizophrenia (Heidelberg, Germany) · 2025Article
- Placebo and nocebo phenomena in schizophrenia spectrum disorders: a narrative review on current knowledge and potential future directions.Psychological medicine · 2025Review
- N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.Brain : a journal of neurology · 2025Article
- The Neurophysiological Features of Anticipation in Schizophrenia: A Cross-Sectional Study of Event-Related Potentials.Consortium psychiatricum · 2025Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia.PLoS biology · 2024Article
- Temporal stability of Bayesian belief updating in perceptual decision-making.Behavior research methods · 2024Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Visualizing threat and trustworthiness prior beliefs in face perception in high versus low paranoia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Flexibility Retained: Unimpaired Updating of Expectations in Schizophrenia.Behavioral sciences (Basel, Switzerland) · 2024Article
- Sensory processing in humans and mice fluctuates between external and internal modes.PLoS biology · 2023Article
- Resolving the Delusion Paradox.Schizophrenia bulletin · 2023Review
- Bayesian accounts of perceptual decisions in the nonclinical continuum of psychosis: Greater imprecision in both top-down and bottom-up processes.PLoS computational biology · 2023Article
- Effects of Hallucination Proneness and Sensory Resolution on Prior Biases in Human Perceptual Inference of Time Intervals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perceptual inference depends on an optimal integration of current sensory evidence with prior beliefs about the environment. Alterations of this process have been related to the emergence of positive symptoms in schizophrenia. However, it has remained unclear whether delusions and hallucinations arise from an increased or decreased weighting of prior beliefs relative to sensory evidence. To investigate the relation of this prior-to-likelihood ratio to positive symptoms in schizophrenia, we devised a novel experimental paradigm which gradually manipulates perceptually ambiguous visual stimuli by disambiguating stimulus information. As a proxy for likelihood precision, we assessed the sensitivity of individual participants to sensory evidence. As a surrogate for the precision of prior beliefs in perceptual stability, we measured phase duration in ambiguity. Relative to healthy controls, patients with schizophrenia showed a stronger increment in congruent perceptual states for increasing levels of disambiguating stimulus evidence. Sensitivity to sensory evidence correlated positively with the individual patients' severity of perceptual anomalies and hallucinations. Moreover, the severity of such experiences correlated negatively with phase duration. Our results indicate that perceptual anomalies and hallucinations are associated with a shift of perceptual inference toward sensory evidence and away from prior beliefs. This reduced prior-to-likelihood ratio in sensory processing may contribute to the phenomenon of aberrant salience, which has been suggested to give rise to the false inferences underlying psychotic experiences.
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