ArticleThe Analyst2020
Optimization of confined direct analysis in real time mass spectrometry (DART-MS).
Article in The Analyst, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Applications of DESI and DART Mass Spectrometry in Forensic Science.Journal of the American Society for Mass Spectrometry · 2025Review
- Rapid Chemical Screening of Microplastics and Nanoplastics by Thermal Desorption and Pyrolysis Mass Spectrometry with Unsupervised Fuzzy Clustering.Analytical chemistry · 2023Article
- Direct analysis in real-time mass spectrometry: Observations of helium, nitrogen and argon as ionisation gas for the detection of small molecules using a single quadrupole instrument.Rapid communications in mass spectrometry : RCM · 2023Article
- Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices.Analytical and bioanalytical chemistry · 2021Article
- Confined DART-MS for Rapid Chemical Analysis of Electronic Cigarette Aerosols and Spiked Drugs.Journal of the American Society for Mass Spectrometry · 2021Article
- DART-MS Spectral Similarity of Infrared Thermally Desorbed Solid Particulate and Solution Cast Propellant Samples.Journal of the American Society for Mass Spectrometry · 2021Article
- Creation and Release of an Updated NIST DART-MS Forensics Database.Journal of the American Society for Mass Spectrometry · 2021Article
- Forensic applications of DART-MS: A review of recent literature.Forensic chemistry (Amsterdam, Netherlands) · 2021Article
- Analysis of benzodiazepines by thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS).Analytical methods : advancing methods and applications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Direct analysis in real time mass spectrometry (DART-MS) is seeing increased use in many fields, including forensic science, environmental monitoring, food safety, and healthcare. With increased use, novel configurations of the system have been created to either aid in detection of traditionally difficult compounds or surfaces, provide a more reproducible analysis, and/or chemically image surfaces. This work focuses on increasing the fundamental understanding of one configuration, where the DART ionization gas is confined in a junction, such as with thermal desorption (TD) DART-MS. Using five representative compounds and a suite of visualization tools, the role of the DART ionization gas, Vapur flow rate, gas back pressure, and exit grid voltage were examined to better understand both the chemical and physical processes occurring inside the confined configuration. The use of nitrogen as a DART ionization gas was found to be more beneficial than helium because of enhanced mixing with the analyte vapors, providing a more reproducible response. Lower Vapur flow rates were also found to be advantageous as they increased the analyte residence time in the junction, thus increasing the probability of its ionization. Operation at even lower Vapur flow rates was achieved by modifying the junction to restrict the DART gas flow. The DART exit grid voltage and gas back pressure had little observed impact on analyte response. These results provide the foundation to better understand and identify best practices for using a confined DART-MS configuration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.