ReviewClinical and translational radiation oncology2020
Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine.
Review in Clinical and translational radiation oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Research-evidence gap analysis of hypofractionated radiotherapy for breast cancer: a bibliometric knowledge graph study.Frontiers in oncology · 2026Pooled it
- Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2021Pooled it
- Pooled it
- Intraoperative Radiotherapy Is Not a Better Alternative to Whole Breast Radiotherapy as a Therapeutic Option for Early-Stage Breast Cancer.Frontiers in oncology · 2021Pooled it
- ASBrS Keynote Address: Reimagining Stage 1 Breast Cancer-Evolution of Breast Cancer Management over the Last 120 Years.Annals of surgical oncology · 2025Article
- Recent Advances in Optimizing Radiation Therapy Decisions in Early Invasive Breast Cancer.Cancers · 2023Review
- Breast cancer relapses considering molecular biological characteristics.Journal of medicine and life · 2023Article
- Optimizing Adjuvant Treatment Recommendations for Older Women with Biologically Favorable Breast Cancer: Short-Course Radiation or Long-Course Endocrine Therapy?Current oncology (Toronto, Ont.) · 2022Review
- Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study.Biomedicines · 2022Article
- Management Strategies for Older Patients with Low-Risk Early-Stage Breast Cancer: A Physician Survey.Current oncology (Toronto, Ont.) · 2021Article
- Experiences and Perceptions of Older Adults with Lower-Risk Hormone Receptor-Positive Breast Cancer about Adjuvant Radiotherapy and Endocrine Therapy: A Patient Survey.Current oncology (Toronto, Ont.) · 2021Article
- Breast cancer patient perspective on opportunities and challenges of a genetic test aimed to predict radio-induced side effects before treatment: Analysis of the Italian branch of the REQUITE project.La Radiologia medica · 2021Article
- Omission of adjuvant radiotherapy for older adults with early-stage breast cancer particularly in the COVID era: A literature review (on the behalf of Italian Association of Radiotherapy and Clinical Oncology).Journal of geriatric oncology · 2021Review
- New classifications of axillary lymph nodes and their anatomical-clinical correlations in breast surgery.World journal of surgical oncology · 2021Review
- Estimation of Annual Secondary Lung Cancer Deaths Using Various Adjuvant Breast Radiotherapy Techniques for Early-Stage Cancers.Frontiers in oncology · 2021Article
- Older age and comorbidity in breast cancer: is RT alone the new therapeutic frontier?Journal of cancer research and clinical oncology · 2020Article
- Analysis of Spatial Distribution and Prognostic Value of Different Pan Cytokeratin Immunostaining Intensities in Breast Tumor Tissue Sections.International journal of molecular sciences · 2020Article
- Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers.American journal of cancer research · 2020Review
- Suggestions for Radiation Oncologists during the COVID-19 Pandemic.BioMed research international · 2020Review
- Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer.Frontiers in oncology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.