Evidence map›Paper›PMID 32090125›Full record

ArticleJournal of diabetes research2020

Exendin-4 Improves Diabetic Kidney Disease in C57BL/6 Mice Independent of Brown Adipose Tissue Activation.

Shu Fang, Yingying Cai, Fuping Lyu, Hongbin Zhang, Chunyan Wu, Yanmei Zeng, Cunxia Fan, Shaozhou Zou, Yudan Zhang, Ping Li and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. New Insights into the Role of Mitochondrial Dysfunction in Diabetic Kidney Disease in the Omics Era.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. PMPeerJ · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Shu FangDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0001-6657-3870
Yingying CaiDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0002-2715-0135
Fuping LyuDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0003-3816-2606
Hongbin ZhangDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark 2200.ORCID https://orcid.org/0000-0003-1109-8878
Chunyan WuDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0002-2489-9634
Yanmei ZengDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0002-9366-6252
Cunxia FanDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0002-5855-7595
Shaozhou ZouDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.
Yudan ZhangDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.
Ping LiDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.
Ling WangDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0003-3839-5231
YaomingXueDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0003-1356-4780
Meiping GuanDepartment of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 510515.ORCID https://orcid.org/0000-0002-9709-9320
Nanfang Hospital · CNTung Wah Hospital · CNUniversity of Copenhagen · DKXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of exendin-4 in brown adipose tissue (BAT) activation was not very clear. This study is to verify the role of BAT involved in renal benefits of exendin-4 in diabetes mellitus (DM).

methodsIn vivo, C57BL/6 mice were randomly divided into nondiabetic (control) and diabetic groups (DM). The diabetic mice were randomized into a control group (DM-Con), BAT-excision group (DM+Exc), exendin-4-treated group (DM+E4), and BAT-excision plus exendin-4-treated group (DM+Exc+E4). The weight, blood glucose and lipids, 24 h urine albumin and 8-OH-dG, and renal fibrosis were analyzed. In vitro, we investigated the role of exendin-4 in the differentiation process of 3T3-L1 and brown preadipocytes and its effect on the rat mesangial cells induced by oleate.

resultsThe expressions of UCP-1, PGC-1

conclusionsExendin-4 could decrease the renal lipid deposit and improve diabetic nephropathy via activating the renal AMPK pathway independent of BAT activation.

Indexed as

3T3-L1 Cells8-Hydroxy-2'-DeoxyguanosineAcyltransferasesAdenylate KinaseAdipocytes, BrownAdipogenesisAdipose Tissue, BrownAlbuminuriaAnimalsBlood GlucoseBlotting, WesternBody WeightCD36 AntigensCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 28-Hydroxy-2'-DeoxyguanosineAcyltransferasesAdenylate KinaseBlood GlucoseCD36 AntigensCd36 protein, mouseCholesterol, HDLCholesterol, LDLExenatideIncretinsLipasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPNPLA2 protein, mousePpargc1a protein, mouseTriglyceridesUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID32090125
PMCPMC7023845
OpenAlexW3004122635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.