ArticleBioMed research international2020
H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease.
Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients.The European journal of neuroscience · 2025Article
- CYP1A1/20-HETE/GPR75 Axis-Mediated Arachidonic Acid Metabolism Dysregulation in H-Type Hypertension Pathogenesis.International journal of molecular sciences · 2025Article
- Severity and Prognosis of Vascular Dementia in Patients with Acute Cerebral Infarction Combined with H-Type Hypertension and Its Correlation with Uric Acid Levels.Neuropsychiatric disease and treatment · 2025Article
- Association between homocysteine and severe cerebral small vessel disease burden in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Association of serum 25-hydroxyvitamin D and homocysteine "double-risk" status with executive dysfunction in older adults with hypertension.Frontiers in nutrition · 2025Article
- Homocysteine, HHcy, H-type hypertension and dizziness: an NHANES analysis.Frontiers in neurology · 2025Article
- Efficacy of Vitamin-D supplementation in improving the prognosis of H-type hypertension in elderly patients.Pakistan journal of medical sciences · 2024Article
- Internal mechanism of correlation between angiotensin II gene and serum adiponectin level in patients with cerebrovascular complications of H-type hypertension.Journal of medical biochemistry · 2024Article
- The effect of cumulative exposure with unhealthy lifestyles on the H-type hypertension among Chinese adults: a community-based, propensity-score-matched, and case-control study.Frontiers in nutrition · 2024Article
- Effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults: a population-based and real-world evidence study.Frontiers in nutrition · 2024Article
- H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China.BMC cardiovascular disorders · 2023Article
- Serum homocysteine level is an independent risk factor for 1-year stroke recurrence in patients with acute ischemic stroke and H-type hypertension: results from the Xi'an stroke registry study of China.Frontiers in neurology · 2023Article
- Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound.Journal of atherosclerosis and thrombosis · 2022Article
- Comparison of the Ameliorating Effects of Valsartan and Amlodipine on Vascular Endothelial Dysfunction and Oxidative Stress in Elderly Patients with Type H Hypertension.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke.Behavioural neurology · 2022Article
- Gender difference in association between H-type hypertension and subcortical ischemic vascular disease.Frontiers in aging neuroscience · 2022Article
- Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018.Frontiers of medicine · 2021Article
- The association between retinal vessel abnormalities and H-type hypertension.BMC neurology · 2021Article
- Hypertension With High Homocysteine Is Associated With Default Network Gray Matter Loss.Frontiers in neurology · 2021Article
- Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China.Disease markers · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe correlation between H-type hypertension and cerebral small-vessel diseases (CSVD) remains uncertain.
objectiveThe present study was designed to explore the possible relationship between H-type hypertension and CSVD spectrum and total burden.
methodWe included 329 patients in the present study and divided them into four groups: the H-type hypertension group, isolated hypertension group, isolated hyperhomocysteinemia (HHcy) group, and control group. Clinical variables of interest and the MR examination sequences were obtained. We counted the presence of each CSVD feature and rated the total burden of CSVD on an ordinal scale from 0 to 4 according to a recent described score rule.
resultThe results showed that H-type hypertension was associated with the presence of cerebral microbleeds (CMBs), and the severity of white-matter hyperintensities (WMHs) and peripheral vascular space (PVS). CSVD total burden was significantly related to age (OR: 1.059, 95% CI: 1.037-1.082), systolic pressure (OR: 1.122, 95% CI: 1.007-1.136), triglycerides (OR: 1.386, 95% CI: 1.037-1.854), isolated HHcy (OR: 4.154, 95% CI 1.836-9.401), and H-type hypertension (OR: 5.028, 95% CI: 2.323-10.883). Also, we further observed hypertension and HHcy had a synergistic effect on CSVD total burden (OR: 2.776, 95% CI: 1.564-4.927).
conclusionH-type hypertension was associated with CSVD total burden and CSVD spectrum, which deserves further prevention measures. Furthermore, hypertension and HHcy had a synergistic effect on CSVD total burden.
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