Evidence map›Paper›PMID 32089894›Full record

ArticleSleep disorders2020

An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional Connectivity in Patients with Insomnia.

George Zabrecky, Shiva Shahrampour, Cutler Whitely, Mahdi Alizadeh, Chris Conklin, Nancy Wintering, Karl Doghramji, Tingting Zhan, Feroze Mohamed, Andrew Newberg and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Sleep disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Systematic review: auditory stimulation and sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

George ZabreckyDepartment of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Shiva ShahrampourDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cutler WhitelyDepartment of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Mahdi AlizadehDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Chris ConklinDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Nancy WinteringDepartment of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Karl DoghramjiSleep Disorders Center, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Tingting ZhanDepartment of Biostatistics, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0000-0001-9971-4844
Feroze MohamedDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Andrew NewbergDepartment of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0000-0001-8230-1752
Daniel MontiDepartment of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Thomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is well known that vibratory and auditory stimuli from vehicles such as cars and trains can help induce sleep. More recent literature suggests that specific types of vibratory and acoustic stimulation might help promote sleep, but this has not been tested with neuroimaging. Thus, the purpose of this study was to observe the effects of vibroacoustic stimulation (providing both vibratory and auditory stimuli) on functional connectivity changes in the brain using resting state functional magnetic resonance imaging (rs-fMRI), and compare these changes to improvements in sleep in patients with insomnia.

methodsFor this study, 30 patients with insomnia were randomly assigned to receive one month of a vibroacoustic stimulation or be placed in a waitlist control. Patients were evaluated pre- and postprogram with qualitative sleep questionnaires and measurement of sleep duration with an actigraphy watch. In addition, patients underwent rs-fMRI to assess functional connectivity.

resultsThe results demonstrated that those patients receiving the vibroacoustic stimulation had significant improvements in measured sleep minutes as well as in scores on the Insomnia Severity Index questionnaire. In addition, significant changes were noted in functional connectivity in association with the vermis, cerebellar hemispheres, thalamus, sensorimotor area, nucleus accumbens, and prefrontal cortex.

conclusionsThe results of this study show that vibroacoustic stimulation alters the brain's functional connectivity as well as improves sleep in patients with insomnia.

Identifiers

PMID32089894
PMCPMC7024098
OpenAlexW3005210128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.