ArticleJournal of ophthalmology2020
Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome.
Article in Journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Prevalence and Etiology of Strabismus in Down Syndrome: A Systematic Review and Meta-Analysis with a Focus on Ethnic Differences in the Esotropia/Exotropia Ratio.Ophthalmic epidemiology · 2025Pooled it
- Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature.Systematic reviews · 2022Pooled it
- The Use of Virtual and Computational Technologies in the Psychomotor and Cognitive Development of Children with Down Syndrome: A Systematic Literature Review.International journal of environmental research and public health · 2022Pooled it
- Comparing visual acuity and optimized visual image quality for individuals with and without Down syndrome.Optometry and vision science : official publication of the American Academy of Optometry · 2025Article
- Developmental wave of programmed ganglion cell death in human retinal organoids.bioRxiv : the preprint server for biology · 2025Article
- Investigating the eye in Down syndrome as a window to Alzheimer's disease: the REVEAL protocol - a clinical cross-sectional study.BMJ open · 2025Article
- Choroidal and retinal vascular changes in adults with Down syndrome: Insights into the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Prevalence and diversity of retinal disease in adults with Down syndrome.Eye (London, England) · 2025Review
- Prevalence of ophthalmic abnormalities and refractive changes in Taiwanese children with Down syndrome.PloS one · 2025Article
- Characterization of autoimmune eye disease in association with Down's syndrome.Eye (London, England) · 2024Article
- Vision Impairments in Young Adults with Down Syndrome.Vision (Basel, Switzerland) · 2023Article
- RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome.Human genomics · 2023Review
- Characterization of autoimmune eye disease in association with Down's Syndrome.Research square · 2023Article
- The Ophthalmic Manifestations of Down Syndrome.Children (Basel, Switzerland) · 2023Review
- Nystagmus in Down Syndrome - a Retrospective Notes Review.The British and Irish orthoptic journal · 2022Article
- Refractive and Vision Status in Down Syndrome: A Comparative StudyTurkish journal of ophthalmology · 2021Article
- Increased choroidal thickness in adults with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Neuro-Ophthalmological Manifestations in Children with Down Syndrome: Current Perspectives.Eye and brain · 2021Review
- Challenges in Patients with Trisomy 21: A Review of Current Knowledge and Recommendations.Journal of ophthalmology · 2021Article
- Down syndrome: a review of ocular manifestations.Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate ocular findings in children with Down syndrome and to compare with the healthy children group.
methodsThe study patients were divided into two groups as the diagnosed Down syndrome group and the control group. The study was designed as a prospective and single-center study in Istanbul University Faculty of Medicine Department of Ophthalmology. The study included 93 patients in the age range from 7 to 18 years, who applied to the ophthalmology department of our clinic in the period from July 2017 to June 2018. The study included the patients allocated into the control group and the Down syndrome patients allocated into the patient group, containing 49 and 44 participants, respectively. All patients underwent complete ophthalmologic examination with biomicroscopy. Autorefractometer measurements were performed in all patients, and the best corrected visual acuity (BCVA) was determined with the use of the Snellen chart. All patients underwent spectral domain optical coherence tomography (SD-OCT) measurements for central foveal retinal (CRT), subfoveal choroidal (CCT), and peripapillary retinal nerve fiber layer (pRNFL) thicknesses.
resultsThe average CRT was 241.2 ± 25.7 microns in Down syndrome group and 219.4 ± 21.1 microns in the control group. There was a statistically significant difference between the groups in regards to CRT (
conclusionsIn the subjects with Down syndrome, the incidence of lens opacities, strabismus, and amblyopia was higher than the control group. CRT and pRNFL were thicker in the Down syndrome group than in control group. This may represent retinal developmental changes in the patients with Down syndrome.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.