Evidence map›Paper›PMID 32089785›Full record

ArticleOxidative medicine and cellular longevity2020

Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2.

Lorenzo Loffredo, Evaristo Ettorre, Anna Maria Zicari, Maurizio Inghilleri, Cristina Nocella, Ludovica Perri, Alberto Spalice, Chiara Fossati, Maria Caterina De Lucia, Fabio Pigozzi and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

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  17. The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Lorenzo LoffredoDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-6542-6235
Evaristo EttorreDepartment of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Division of Gerontology, Sapienza University of Rome, Rome, Italy.
Anna Maria ZicariDepartment of Pediatrics, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-2476-1790
Maurizio InghilleriDepartment of Human Neuroscience, Sapienza University, Rome, Italy.
Cristina NocellaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Ludovica PerriDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Alberto SpaliceDepartment of Pediatrics, Sapienza University of Rome, Italy.
Chiara FossatiDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Italy.
Maria Caterina De LuciaUTNA, IRCCS Neuromed Pozzilli, Isernia, Italy.
Fabio PigozziDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Italy.
Mauro CacciafestaDepartment of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Division of Gerontology, Sapienza University of Rome, Rome, Italy.
Francesco VioliDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Roberto CarnevaleDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.ORCID https://orcid.org/0000-0002-6216-9595
Neurodegenerative Disease study group
Sapienza University of Rome · ITClinica Mediterranea · ITForo Italico University of Rome · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurodegenerative diseases (ND) as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis represent a growing cause of disability in the developed countries. The underlying physiopathology is still unclear. Several lines of evidence suggest a role for oxidative stress and NADPH oxidase 2 (NOX2) in the neuropathological pathways that lead to ND. Furthermore, recent studies hypothesized a role for gut microbiota in the neuroinflammation; in particular, lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut is believed to play a role in causing ND by increase of oxidative stress and inflammation. The aim of this study was to assess NOX2 activity as well as serum 8-iso-prostaglandin F2

methodsOne hundred and twenty-eight consecutive subjects, including 64 ND patients and 64 controls (CT) matched for age and gender, were recruited. A cross-sectional study was performed to compare serum activity of soluble NOX2-dp (sNOX2-dp), blood levels of isoprostanes, serum H

resultsCompared with CT, ND patients had higher values of sNOX2-dp, 8-iso-PGF2

conclusionThis study provides the first report attesting that patients with ND have high NOX2 activation that could be potentially implicated in the process of neuroinflammation.

Indexed as

AgedFemaleHumansLipopolysaccharidesMaleNADPH Oxidase 2Neurodegenerative DiseasesOxidative StressLipopolysaccharidesNADPH Oxidase 2

Identifiers

PMID32089785
PMCPMC7016401
OpenAlexW3004090161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.