ArticleDisease markers2020
Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population.
Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Effect of roasted purple laver (nori) on vitamin BEuropean journal of nutrition · 2024Trial
- Trial
- Determination of method-specific reference intervals for vitamin B12 and its correlation with holotranscobalamin.Biochemia medica · 2026Article
- Pernicious Anemia: Basic Pathophysiology and Diagnostic Challenges in Neuropsychiatric Patients.Hematology reports · 2026Review
- The Diagnostic Accuracy of Methylmalonic Acid to Detect Inadequate Vitamin B-12 Status Relative to 3cB-12 Was Higher Compared with That of Total Cobalamin and Total Homocysteine in a Cross-Sectional Survey of Apparently Healthy US Adults.Current developments in nutrition · 2026Article
- Vitamin BNutrients · 2026Review
- B vitamins and cardiovascular health: mechanisms, clinical evidence, and precision prevention strategies.Nutrition & metabolism · 2026Review
- Vitamin B12 deficiency: testing and treatment.Australian prescriber · 2026Review
- Vitamin B12 Deficiency in the Diagnostic Work-Up of Global Developmental Delay: A Treatable and Time-Sensitive Condition.Nutrients · 2026Review
- Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Review
- Review
- The effect of parenteral vitamin BScientific reports · 2025Article
- Foundations of Pediatric Lifestyle Medicine.Children (Basel, Switzerland) · 2025Article
- Comparison of diagnostic algorithms used in guidelines on nutritional anaemias in adults.PloS one · 2025Article
- Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference-Case report.SAGE open medical case reports · 2025Article
- The clinical utility and cost-effectiveness of routine vitamin BThe South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- The application and interpretation of laboratory biomarkers for the evaluation of vitamin B12 status.Annals of clinical biochemistry · 2025Review
- Vitamin B12 deficiency in dialysis patients: risk factors, diagnosis, complications, and treatment: A comprehensive review.World journal of nephrology · 2024Review
- An Unusual Case of Hemolytic Anemia: A Case Report.Cureus · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four biomarkers are commonly employed to diagnose B12 deficiency: vitamin B12 (B12), holotranscobalamin (HoloTC), methylmalonic acid (MMA), and homocysteine (Hcy). 4cB12, a combined index of the B12 status, has been suggested to improve the recognition of B12 deficiency. We aimed to evaluate the four different markers for detecting B12 deficiency, as determined by 4cB12. Within a large, mixed patient population, 11,833 samples had concurrent measurements of B12, HoloTC, MMA, and Hcy. 4cB12 was calculated according to the methods described by Fedosov. Diagnostic cutoffs as well as diagnostic accuracy for the detection of B12 deficiency were assessed with receiver operating characteristic (ROC) analysis. The median age was 56 years, and women accounted for 58.8% of the samples. Overall, the area under the curve (AUC) for the detection of subclinical B12 deficiency was highest for HoloTC (0.92), followed by MMA (0.91), B12 (0.9) and Hcy (0.78). The difference between HoloTC and B12 was driven by a significantly higher AUC for HoloTC (0.93) than for B12 (0.89), MMA (0.91), and Hcy in women 50 years and older (0.79;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.