Evidence map›Paper›PMID 32089747›Full record

ArticleTheranostics2020

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging.

Henriette S de Bruijn, Vida Mashayekhi, Tom J L Schreurs, Pieter B A A van Driel, Gustav J Strijkers, Paul J van Diest, Clemens W G M Lowik, Ann L B Seynhaeve, Timo L M Ten Hagen, Jeanine J Prompers and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. A Photosensitized Singlet Oxygen (Molecules (Basel, Switzerland) · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Henriette S de BruijnCenter for Optical Diagnostics and Therapy, Dept. of Otolaryngology and Head & Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Vida MashayekhiCell Biology Division, Dept. of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Tom J L SchreursBiomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Pieter B A A van DrielDivision of Optical Molecular Imaging, Dept. of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Gustav J StrijkersAmsterdam University Medical Centers, University of Amsterdam, Dept. of Biomedical Engineering and Physics, The Netherlands.
Paul J van DiestDept. of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Clemens W G M LowikDivision of Optical Molecular Imaging, Dept. of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Ann L B SeynhaeveLaboratory of Experimental Oncology, Dept. of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Timo L M Ten HagenLaboratory of Experimental Oncology, Dept. of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Jeanine J PrompersBiomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Paul M P van Bergen En HenegouwenCell Biology Division, Dept. of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Dominic J RobinsonCenter for Optical Diagnostics and Therapy, Dept. of Otolaryngology and Head & Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Sabrina OliveiraCell Biology Division, Dept. of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Eindhoven University of Technology · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted photodynamic therapy (PDT) has the potential to selectively damage tumor tissue and to increase tumor vessel permeability. Here we characterize the tissue biodistribution of two EGFR-targeted nanobody-photosensitizer conjugates (NB-PS), the monovalent 7D12-PS and the biparatopic 7D12-9G8-PS. In addition, we report on the local and acute phototoxic effects triggered by illumination of these NB-PS which have previously shown to lead to extensive tumor damage.

Indexed as

AnimalsCell Line, TumorDrug Delivery SystemsEndothelial CellsErbB ReceptorsHead and Neck NeoplasmsIntravital MicroscopyMagnetic Resonance ImagingMiceNanoparticlesOptical ImagingPhotochemotherapyPhotosensitizing AgentsSquamous Cell Carcinoma of Head and NeckTissue DistributionErbB ReceptorsPhotosensitizing AgentsEGFRIntravital microscopy.NanobodyPhotodynamic therapyPhotosensitizerTargeted

Identifiers

PMID32089747
PMCPMC7019176
OpenAlexW3004001072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.