Evidence map›Paper›PMID 32089743›Full record

ArticleTheranostics2020

Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.

Yin Hu, Yan Zhang, Chu-Yu Ni, Chun-Yuan Chen, Shan-Shan Rao, Hao Yin, Jie Huang, Yi-Juan Tan, Zhen-Xing Wang, Jia Cao and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 6 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 6 syntheses or guidelines pooled it, 169 citations in OpenAlex.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Yin HuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yan ZhangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chu-Yu NiDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
Chun-Yuan ChenDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Shan-Shan RaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Hao YinDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jie HuangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yi-Juan TanMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zhen-Xing WangMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jia CaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zheng-Zhao LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Ping-Li XieDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China.
Ben WuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Juan LuoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Hui XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis and osteoporotic fractures severely compromise quality of life in elderly people and lead to early death. Human umbilical cord mesenchymal stromal cell (MSC)-derived extracellular vesicles (hucMSC-EVs) possess considerable therapeutic effects in tissue repair and regeneration. Thus, in the present study, we investigated the effects of hucMSC-EVs on primary and secondary osteoporosis and explored the underlying mechanisms.

Indexed as

AdipocytesAdipogenesisAnimalsBone and BonesBone MarrowCell DifferentiationChondrocytesDisease Models, AnimalExtracellular VesiclesHematopoietic Cell Growth FactorsHumansLectins, C-TypeMesenchymal Stem CellsMiceOsteoblastsOsteogenesisCLEC11A protein, humanHematopoietic Cell Growth FactorsLectins, C-Typebone homeostasisCLEC11Aextracellular vesiclesosteoporosisumbilical cord-derived mesenchymal stromal cells

Identifiers

PMID32089743
PMCPMC7019162
OpenAlexW3004055518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.