Evidence map›Paper›PMID 32089709›Full record

ReviewStem cells international2020

Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications.

Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Marwa M S Abbass, Aiah A El-Rashidy, Khadiga M Sadek, Christof E Dörfer, Karim M Fawzy El-Sayed

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 125 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sara El MoshyOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Israa Ahmed RadwanOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-8262-5941
Dina RadyOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Marwa M S AbbassOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Aiah A El-RashidyStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Khadiga M SadekStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Christof E DörferClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.
Karim M Fawzy El-SayedStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-6261-3609
Cairo University · EGChristian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue' diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs' secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.

Identifiers

PMID32089709
PMCPMC7013327
OpenAlexW3003810972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.