Evidence map›Paper›PMID 32089591›Full record

ArticleInternational dairy journal2020

Production of functional mimics of human milk oligosaccharides by enzymatic glycosylation of bovine milk oligosaccharides.

Valerie Weinborn, Yanhong Li, Ishita M Shah, Hai Yu, David C Dallas, J Bruce German, David A Mills, Xi Chen, Daniela Barile

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dairy journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Valerie WeinbornDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Yanhong LiGlycohub, Inc., 4070 Truxel Road, Sacramento, CA 95834, USA.
Ishita M ShahDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Hai YuGlycohub, Inc., 4070 Truxel Road, Sacramento, CA 95834, USA.
David C DallasNutrition Program, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.
J Bruce GermanDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
David A MillsDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Xi ChenDepartment of Chemistry, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Daniela BarileDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
University of California, Davis · USEpic Bible College · USOregon State University · US

Funding

Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Oligosaccharides as antimicrobials and prebioticsR01HD065122 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2010 to 2013
$1.8M
Enzymatic modification of isolated bovine milk oligosaccharides to mimic human milk oligosaccharides with increased antimicrobial activityR43HD083981 · NICHD · GLYCOHUB, INC. · PI BARILE, DANIELA, DALLAS, DAVID CHARLES · 2015 to 2015
$150k
NCCIH NIH HHS R01 AT008759NICHD NIH HHS R01 HD065122NICHD NIH HHS R43 HD083981
6 · The paper itself

Abstract

Consumption of mothers' milk is associated with reduced incidence and severity of enteric infections, leading to reduced morbidity in breastfed infants. Fucosylated and sialylated human milk oligosaccharides (HMO) are important for both direct antimicrobial action - likely via a decoy effect - and indirect antimicrobial action through commensal growth enhancement. Bovine milk oligosaccharides (BMO) are a potential source of HMO-mimics as BMO resemble HMO; however, they have simpler and less fucosylated structures. BMO isolated at large scales from bovine whey permeate were modified by the addition of fucose and/or sialic acid to generate HMO-like glycans using high-yield and cost-effective one-pot multienzyme approaches. Quadrupole time-of-flight LC/MS analysis revealed that 22 oligosaccharides were synthesized and 9 had identical composition to known HMO. Preliminary anti-adherence activity assays indicated that fucosylated BMO decreased the uptake of enterohemorrhagic

Identifiers

PMID32089591
PMCPMC7034812
OpenAlexW2987552651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.