Evidence map›Paper›PMID 32089451›Full record

ReviewRedox biology2020

Mechanisms of exercise-induced preconditioning in skeletal muscles.

Scott K Powers, Matthew Bomkamp, Mustafa Ozdemir, Hayden Hyatt

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Mitochondrial Biogenesis in Skeletal Muscle.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mitochondrial Bioenergetics and Turnover during Chronic Muscle Disuse.International journal of molecular sciences · 2021
    Review
  14. Review
  15. The COVID-19 pandemic and physical activity.Sports medicine and health science · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Scott K PowersDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
Matthew BomkampDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA. Electronic address: mbomkamp@ufl.edu.
Mustafa OzdemirDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
Hayden HyattDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
University of Florida · US

Funding

Mechanisms of exercise protection in ventilator-induced diaphragm dysfunctionR01AR064189 · NIAMS · UNIVERSITY OF FLORIDA · PI POWERS, SCOTT K. · 2013 to 2017
$2.2M
Title: Ventilator-induced diaphragm dysfunction: role of calpain signalingR21AR073956 · NIAMS · UNIVERSITY OF FLORIDA · PI POWERS, SCOTT K. · 2019 to 2020
$369k
NIAMS NIH HHS R01 AR064189NIAMS NIH HHS R21 AR073956
6 · The paper itself

Abstract

Endurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal muscle fibers is commonly termed "exercise preconditioning". This review will discuss the biochemical mechanisms responsible for exercise-induced protection of skeletal muscle fibers against these harmful events. The first segment of this report highlights the evidence that endurance exercise training provides cytoprotection to skeletal muscle fibers against several potentially damaging insults. The second and third sections of the review will discuss the cellular adaptations responsible for exercise-induced protection of skeletal muscle fibers against doxorubicin-provoked damage and inactivity-induced fiber atrophy, respectively. Importantly, we also identify gaps in our understanding of exercise preconditioning in hopes of stimulating future research.

Indexed as

Muscle, SkeletalMuscular AtrophyAdaptation, PhysiologicalExerciseHumansMuscle Fibers, SkeletalDiaphragmDoxorubicinEndurance exerciseHeartMechanical ventilationMuscle atrophyMuscle wasting

Identifiers

PMID32089451
PMCPMC7284917
OpenAlexW3006376228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.