Evidence map›Paper›PMID 32089111›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020

Analysing brain networks in population neuroscience: a case for the Bayesian philosophy.

Danilo Bzdok, Dorothea L Floris, Andre F Marquand

Abstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  14. Unifying the essential concepts of biological networks: biological insights and philosophical foundations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Danilo BzdokDepartment of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, McGill University, Montreal, Canada.
Dorothea L FlorisDepartment of Cognitive Neuroscience, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Andre F MarquandDepartment of Cognitive Neuroscience, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Funding

Wellcome Trust 215698/Z/19/Z
6 · The paper itself

Abstract

Network connectivity fingerprints are among today's best choices to obtain a faithful sampling of an individual's brain and cognition. Widely available MRI scanners can provide rich information tapping into network recruitment and reconfiguration that now scales to hundreds and thousands of humans. Here, we contemplate the advantages of analysing such connectome profiles using Bayesian strategies. These analysis techniques afford full probability estimates of the studied network coupling phenomena, provide analytical machinery to separate epistemological uncertainty and biological variability in a coherent manner, usher us towards avenues to go beyond binary statements on existence versus non-existence of an effect, and afford credibility estimates around all model parameters at play which thus enable single-subject predictions with rigorous uncertainty intervals. We illustrate the brittle boundary between healthy and diseased brain circuits by autism spectrum disorder as a recurring theme where, we argue, network-based approaches in neuroscience will require careful probabilistic answers. This article is part of the theme issue 'Unifying the essential concepts of biological networks: biological insights and philosophical foundations'.

Indexed as

Autism Spectrum DisorderBayes TheoremNerve NetBrainConnectomeHumansNeurosciencesPhilosophyconfounding influencesconnectome-based predictionstatistical learninguncertainty

Identifiers

PMID32089111
PMCPMC7061951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.