Evidence map›Paper›PMID 32089055›Full record

ArticleJournal of the American Heart Association2020

Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.

Edmund B Chen, Katherine E Shapiro, Kelly Wun, Thomas Kuntz, Betty R Theriault, Michael J Nooromid, Vanessa A Leone, Katharine G Harris, Qun Jiang, Melanie Spedale and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Edmund B ChenDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Katherine E ShapiroDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Kelly WunDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Thomas KuntzDepartment of Chemistry University of Chicago IL.
Betty R TheriaultDepartment of Surgery University of Chicago IL.
Michael J NooromidDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Vanessa A LeoneSection of Gastroenterology Department of Medicine University of Chicago IL.
Katharine G HarrisSection of Gastroenterology Department of Medicine University of Chicago IL.
Qun JiangDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Melanie SpedaleAnimal Resources Center University of Chicago IL.
Liqun XiongDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Jack A GilbertDepartment of Pediatrics and Scripps Institution of Oceanography University of California San Diego La Jolla CA.
Eugene B ChangSection of Gastroenterology Department of Medicine University of Chicago IL.
Karen J HoDepartment of Surgery Northwestern University Feinberg School of Medicine Chicago IL.
Northwestern University · USUniversity of Chicago · USScripps Institution of Oceanography · USUniversity of Illinois Chicago · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 1990 to 2025
$29.8M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
PSEUDOMONAS'EFFECTS ON THE GUT BARRIER FROM SURGERYR01GM062344 · NIGMS · UNIVERSITY OF CHICAGO · PI ALVERDY, JOHN C · 2001 to 2025
$9.2M
Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01)U01DK106786 · NIDDK · UNIVERSITY OF MINNESOTA · PI HARLOW, BERNARD L, RUDSER, KYLE · 2015 to 2019
$8.4M
Vascular Surgery Scientist Training ProgramT32HL094293 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ESKANDARI, MARK K · 2009 to 2023
$4.0M
Gut microbiota, short chain fatty acids, and adiposity across the epidemiologic transitionR01DK111848 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI DUGAS, LARA RUTH · 2017 to 2021
$3.0M
The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of AgeR01NR015446 · NINR · UNIVERSITY OF SOUTH FLORIDA · PI GROER, MAUREEN EDITH · 2015 to 2019
$2.6M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
The Role of Gut Microbiota in Neointimal Hyperplasia After Vascular InjuryK08HL130601 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HO, KAREN J. · 2016 to 2020
$801k
Azithromycin and the airway microbiome in asthmaR34HL136991 · NHLBI · UNIVERSITY OF CHICAGO · PI ROSENBERG, SHARON R., WHITE, STEVEN R · 2018 to 2019
$735k
Diurnal Oscillations in Gut Microbes and Host Immunity in Health and ObesityK01DK111785 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LEONE, VANESSA ANNE · 2017 to 2021
$723k
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS K08 HL130601NHLBI NIH HHS R34 HL136991NHLBI NIH HHS T32 HL094293NICHD NIH HHS R03 HD095056NIDDK NIH HHS F32 DK113743NIDDK NIH HHS K01 DK111785NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK097268NIDDK NIH HHS R01 DK111848NIDDK NIH HHS R56 DK102872NIDDK NIH HHS T32 DK007074NIDDK NIH HHS U01 DK106786NIGMS NIH HHS R01 GM062344NINR NIH HHS R01 NR015446
6 · The paper itself

Abstract

Background The potential role of the gut microbiome in cardiovascular diseases is increasingly evident. Arterial restenosis attributable to neointimal hyperplasia after cardiovascular procedures such as balloon angioplasty, stenting, and bypass surgery is a common cause of treatment failure, yet whether gut microbiota participate in the development of neointimal hyperplasia remains largely unknown. Methods and Results We performed fecal microbial transplantation from conventionally raised male C57BL/6 mice to age-, sex-, and strain-matched germ-free mice. Five weeks after inoculation, all mice underwent unilateral carotid ligation. Neointimal hyperplasia development was quantified after 4 weeks. Conventionally raised and germ-free cohorts served as comparison groups. Conclusions Germ-free mice have significantly attenuated neointimal hyperplasia development compared with conventionally raised mice. The arterial remodeling response is restored by fecal transplantation. Our results describe a causative role of gut microbiota in contributing to the pathogenesis of neointimal hyperplasia.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeNeointimaAnimalsCarotid ArteriesCarotid Artery InjuriesDisease Models, AnimalGerm-Free LifeHyperplasiaMaleMice, Inbred C57BLmicrobiomeneointimal hyperplasiarestenosis

Identifiers

PMID32089055
PMCPMC7335569
OpenAlexW3008439494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.