ArticleAmerican journal of physiology. Renal physiology2020
A mathematical model of the rat kidney. II. Antidiuresis.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- High dietary KAmerican journal of physiology. Renal physiology · 2023Article
- A mathematical model of the rat kidney. III. Ammonia transport.American journal of physiology. Renal physiology · 2021Article
- Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease.JCI insight · 2021Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
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Abstract
Kidney water conservation requires a hypertonic medullary interstitium, NaCl in the outer medulla and NaCl and urea in the inner medulla, plus a vascular configuration that protects against washout. In this work, a multisolute model of the rat kidney is revisited to examine its capacity to simulate antidiuresis. The first step was to streamline model computation by parallelizing its Jacobian calculation, thus allowing finer medullary spatial resolution and more extensive examination of model parameters. It is found that outer medullary NaCl is modestly increased when transporter density in ascending Henle limbs from juxtamedullary nephrons is scaled to match the greater juxtamedullary solute flow. However, higher NaCl transport produces greater CO
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