SynthesisEuropean child & adolescent psychiatry2021
Early non-social behavioural indicators of autism spectrum disorder (ASD) in siblings at elevated likelihood for ASD: a systematic review.
Synthesis in European child & adolescent psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A systematic review and meta-analysis of atypical visual attention towards non-social stimuli in preschoolers with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024Pooled it
- Movement-Related Differences Between Infants with High and Low Likelihood of Autism: A Longitudinal Study Using Markerless Motion Tracking.Sensors (Basel, Switzerland) · 2026Article
- Early Detection Methods for Autism Spectrum Disorder: From Clinical Screening to Multimodal AI.Diagnostics (Basel, Switzerland) · 2026Review
- A Concurrent Validity Study of the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI) in Infants with an Elevated Likelihood or Diagnosis of Autism.Journal of autism and developmental disorders · 2026Article
- Investigating Parental Observations of Early Autism Development in Simplex and Multiplex Families.Journal of autism and developmental disorders · 2026Article
- Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism.Journal of autism and developmental disorders · 2026Article
- Sex-specific vulnerabilities in early human neurodevelopment following SARS-CoV-2-induced maternal immune activation.European child & adolescent psychiatry · 2026Article
- Prodromal behavioral markers and developmental trajectories of autism spectrum disorder in infancy: a narrative review.Frontiers in pediatrics · 2026Review
- CXCL1, RANTES, IFN-γ, and TMAO as Differential Biomarkers Associated with Cognitive Change After an Anti-Inflammatory Diet in Children with ASD and Neurotypical Peers.Medical sciences (Basel, Switzerland) · 2025Article
- Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025Article
- Investigating autistic hyperfocus and monotropism: Limited convergence of event-related potentials, laboratory tasks, and questionnaire responses.Research in autism · 2025Article
- Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People.Journal of autism and developmental disorders · 2025Article
- Fine Motor Ability and Executive Function in Autistic and Non-autistic Toddlers.Journal of autism and developmental disorders · 2025Article
- Object Exploration and Manipulation in Infants at Typical vs. Elevated Likelihood for ASD: A Review.Children (Basel, Switzerland) · 2024Review
- Categorizing and identifying preferred interests in autistic toddlers.Autism research : official journal of the International Society for Autism Research · 2024Article
- Exploring early life social and executive function development in infants and risk for autism: a prospective cohort study protocol of NICU graduates and infants at risk for cerebral palsy.BMC psychiatry · 2024Article
- Implementing an Early Detection Program for Autism Spectrum Disorders in the Polish Primary Healthcare Setting-Possible Obstacles and Experiences from Online ASD Screening.Brain sciences · 2024Article
- Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task.Psychopharmacology · 2024Article
- Perceived quality of parent-child interaction in parents of autistic children: relationship with parental education level.Frontiers in psychiatry · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
We aimed at identifying early non-social behavioural indicators that predict later ASD. Likewise, we were interested in the moment in which non-social signs discriminate between children at elevated likelihood for ASD with a later diagnosis of ASD, and children at elevated likelihood for ASD with a typical developmental outcome. In addition, we intended to explore the developmental evolution of children's symptomatology over time. A systematic literature search was conducted for longitudinal studies on early non-social behavioural indicators among siblings at elevated likelihood for ASD. The following databases were searched: PUBMED, Web of Science, PsycINFO, CINAHL and EMBASE. The study identification process was conducted by two reviewers independently. Compared to siblings at elevated likelihood for ASD with a typical developmental outcome, siblings at elevated likelihood for ASD with later ASD show impairments in attention disengagement, in gross and fine motor development and characteristic restricted and repetitive interests and behaviours, starting at 12 months of age. Moreover, early attention disengagement exerts a predictive role towards a later ASD diagnosis, given that from 12 months siblings at elevated likelihood for ASD who will receive an independent ASD diagnosis towards 24-36 months present marked difficulties in disengaging in comparison with siblings at elevated likelihood for ASD that will not satisfy the criteria for an ASD diagnosis. The findings call for a more comprehensive vision on early indicators of ASD. Further research is needed to extend results to other behavioural domains.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.