Evidence map›Paper›PMID 32088803›Full record

ArticleFamilial cancer2020

Increased prevalence of Barrett's esophagus in patients with MUTYH-associated polyposis (MAP).

Ceranza G Daans, Zeinab Ghorbanoghli, Mary E Velthuizen, Hans F A Vasen, George J A Offerhaus, Miangela M Lacle, Peter D Siersema, Margreet G E M Ausems, Jurjen J Boonstra

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Familial cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ceranza G DaansDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
Zeinab GhorbanoghliThe Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands.
Mary E VelthuizenDepartment of Genetics, University Medical Center Utrecht (Location WKZ), Lundlaan 6, 3584 EA, Utrecht, The Netherlands.
Hans F A VasenThe Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands.
George J A OfferhausDepartment of Pathology, University Medical Center Utrecht, PO BOX 855000, 3508 GA, Utrecht, The Netherlands.
Miangela M LacleDepartment of Pathology, University Medical Center Utrecht, PO BOX 855000, 3508 GA, Utrecht, The Netherlands.
Peter D SiersemaDepartment of Gastroenterology, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
Margreet G E M AusemsDepartment of Gastroenterology & Hepatology, Leiden University Medical Center, PO BOX 9600, 2300 RC, Leiden, The Netherlands.
Jurjen J BoonstraDepartment of Gastroenterology & Hepatology, Leiden University Medical Center, PO BOX 9600, 2300 RC, Leiden, The Netherlands. J.J.Boonstra@lumc.nl.
Leiden University Medical Center · NLUniversity Medical Center Utrecht · NLAmsterdam UMC Location VUmc · NLNetherlands Consortium for Healthy Ageing · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Barrett's oesophagus (BE) has been associated with an increased risk of both colorectal adenomas and colorectal cancer. A recent investigation reported a high frequency of BE in patients with adenomatous polyposis coli (APC)-associated polyposis (FAP). The aim of the present study is to evaluate the prevalence of BE in a large cohort of patients with MUTYH-associated polyposis (MAP) and APC-associated adenomatous polyposis. Patients with a genetically confirmed diagnosis of familial adenomatous polyposis (FAP) or MAP were selected and upper gastrointestinal (GI) endoscopy reports, pathology reports of upper GI biopsies were reviewed to determine the prevalence of BE in these patients. Histologically confirmed BE was found in 7 (9.7%) of 72 patients with MAP. The mean age of diagnosis was 60.2 years (range 54.1-72.4 years). Two patients initially diagnosed with low grade dysplasia showed fast progression into high grade dysplasia and esophageal cancer, respectively. Only 4 (1.4%) of 365 patients with FAP were found to have pathologically confirmed BE. The prevalence of BE in patients with MAP is much higher than reported in the general population. We recommend that upper GI surveillance of patients with MAP should not only focus on the detection of gastric and duodenal adenomas but also on the presence of BE.

Indexed as

AdenocarcinomaAdenomatous Polyposis ColiAdultAgedAged, 80 and overBarrett EsophagusBiopsyDNA GlycosylasesEndoscopy, GastrointestinalEsophageal NeoplasmsFemaleHumansMaleMiddle AgedPrevalenceDNA GlycosylasesmutY adenine glycosylaseBarrett’s esophagusEsophageal adenocarcinomaFamilial adenomatous polyposisMUTYH-associated polyposis

Identifiers

PMID32088803
PMCPMC7101286
OpenAlexW3007824081

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.