ArticleDrug and alcohol dependence2020
Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 81 citations in OpenAlex.
- Mental Health Distress Is Associated With Higher Pain Interference in Patients With Opioid Use Disorder Stabilized on Buprenorphine or Methadone.Substance use & addiction journal · 2024Trial
- Trauma exposure across the lifespan among individuals engaged in treatment with medication for opioid use disorder: differences by gender, PTSD status, and chronic pain.Substance abuse treatment, prevention, and policy · 2024Trial
- Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements.CNS neuroscience & therapeutics · 2026Review
- Buprenorphine Microinduction Treatment in Tri-Diagnosis Patients with Opioid Use Disorder and Chronic Non-Cancerous Pain.Current pain and headache reports · 2026Review
- Integrating Pain Assessment in Nicotine and Tobacco Research and Treatment to Improve Cessation Outcomes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Development and Validation of an Electronic Health Record-Based Algorithm for Identifying Patients With Long-Term Opioid Therapy: Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Pain and Cognitive Concerns Among Breast Cancer Survivors: The Mediating Role of Substance Use Coping.Cancer medicine · 2025Article
- Cost disparities between pain and opioid use disorder formulations of buprenorphine in US health care system: a cross-sectional analysis.Pain medicine (Malden, Mass.) · 2025Article
- Exploring Passion for Opioid Use with a Treatment-Seeking Sample: Results from a Canonical Correlation Analysis.Addiction research & theory · 2025Article
- Opioid prescription patterns and pain severity among patients with opioid use disorder and other substance use disorders: a mixed methods study.Pain reports · 2025Article
- Breast cancer screening among individuals with a substance use disorder: a retrospective cohort study.Family practice · 2025Article
- Recent advances in the treatment of chronic pain and substance use disorders.Current opinion in psychology · 2025Review
- The Intersection of Rurality, Unmet Treatment Need, and Cannabis Use for Adults with Chronic Pain.Cannabis (Albuquerque, N.M.) · 2025Article
- Pain prospectively predicts alcohol use disorder among people living with HIV: A commentary on Palfai et al. (2024).Alcohol, clinical & experimental research · 2025Article
- Chronic Pain and Substance Use Disorders: A Brief Narrative Review of Genetic, Neurobiological, and Environmental Contributions to Comorbidity.Journal of psychiatry and brain science · 2025Article
- The Association Between Chronic Pain, Substance use, and Primary Care Experience Among Veterans with Ongoing or Recent Homelessness.Journal of general internal medicine · 2024Article
- Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder.Drug and alcohol dependence · 2024Article
- Preliminary Validation of a General Factor Model of Chronic Overlapping Pain Conditions.The journal of pain · 2024Article
- Pain Predicts Dropout From Substance Use Treatment.Journal of studies on alcohol and drugs · 2024Article
- Performance of International Classification of Disease-10 codes in detecting emergency department patients with opioid misuse.Addiction (Abingdon, England) · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic non-cancer pain (CNCP) among patients with substance use disorder (SUD) poses a risk for worse treatment outcomes. Understanding the association of CNCP with SUD is important for informing the need and potential benefits of pain assessment/management among those with SUDs.
methodsWe analyzed electronic health record data from 2013 to 2018 among adults aged ≥18 years (N = 951,533; mean age: 48.4 years; 57.4 % female) in a large academic healthcare system. Adjusted logistic regression models were conducted to estimate the association of CNCP conditions with opioid overdose, emergency department utilization, and inpatient hospitalization stratified by different SUD diagnoses and by gender.
resultsAmong the total sample, the prevalence of CNCP was 46.6 % and any SUD was 11.2 %. The majority of patients with a SUD had CNCP (opioid: 74.7 %; sedative: 72.3 %; cannabis: 64.3 %; alcohol: 58.7 %; tobacco: 59.5 %). The prevalence of CNCP was greater in females vs. males for most SUD diagnoses. The presence of CNCP was associated with more mental health disorders and chronic medical conditions among each SUD group. CNCP was associated with significantly decreased odds of overdose among those with opioid use disorder but increased odds of overdose and healthcare utilization among other SUDs. CNCP was positively associated with overdose in females, but not males, with alcohol or non-opioid drug use disorders.
conclusionsThe direction and magnitude of the association between CNCP and negative health indicators differed as a function of SUD type and gender, respectively. Greater awareness of potential unmet pain treatment need may have implications for improving SUD outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.