Evidence map›Paper›PMID 32088061›Full record

ArticleUltrasound in medicine & biology2020

Focused Ultrasound Platform for Investigating Therapeutic Neuromodulation Across the Human Hippocampus.

Spencer T Brinker, Frank Preiswerk, Phillip J White, Timothy Y Mariano, Nathan J McDannold, Ellen J Bubrick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  15. Ultrasound Neuromodulation as a New Brain Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  16. [Modulation of motor responses and neural activities with transcranial ultrasound stimulation based on closed-loop control].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Spencer T BrinkerDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Frank PreiswerkDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phillip J WhiteDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Physics, Simmons College, Boston, Massachusetts, USA.
Timothy Y MarianoCenter for Neurorestoration and Neurotechnology, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA; Butler Hospital, Providence, Rhode Island, USA; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nathan J McDannoldDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: njm@bwh.harvard.edu.
Ellen J BubrickDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: ebubrick@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Multidisciplinary Training in Image-Guided TherapyR25CA089017 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2001 to 2017
$7.8M
Ultrasound-induced blood-brain/tumor barrier disruption in brain metastasesP01CA174645 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCDANNOLD, NATHAN J. · 2013 to 2017
$6.2M
Non-invasive targeted neuromodulation via focused ultrasound BBB permeabilizationR01MH116858 · NIMH · HARVARD MEDICAL SCHOOL · PI LIVINGSTONE, MARGARET S, MCDANNOLD, NATHAN J. · 2018 to 2021
$2.4M
NCI NIH HHS P01 CA174645NCI NIH HHS R25 CA089017NIMH NIH HHS R01 MH116858
6 · The paper itself

Abstract

Pulsed low-intensity focused ultrasound (PLIFUS) has shown promise in inducing neuromodulation in several animal and human studies. Therefore, it is of clinical interest to develop experimental platforms to test repetitive PLIFUS as a therapeutic modality in humans with neurologic disorders. In the study described here, our aim was to develop a laboratory-built experimental device platform intended to deliver repetitive PLIFUS across the hippocampus in seizure onset zones of patients with drug-resistant temporal lobe epilepsy. The system uses neuronavigation targeting over multiple therapeutic sessions. PLIFUS (548 kHz) was emitted across multiple hippocampal targets in a human subject with temporal lobe epilepsy using a mechanically steered piezoelectric transducer. Stimulation was delivered up to 2.25 W/cm

Indexed as

AdultAnimalsEpilepsy, Temporal LobeFemaleHippocampusHumansMagnetic Resonance ImagingNeuronavigationUltrasonic TherapyHuman hippocampusLow-intensity focused ultrasoundMultitargetNeuronavigationTherapeutic neuromodulation

Identifiers

PMID32088061
PMCPMC7239323
OpenAlexW3007367430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.