Evidence map›Paper›PMID 32088018›Full record

Trial reportVaccine2020

Predictors of oral rotavirus vaccine immunogenicity in rural Zimbabwean infants.

James A Church, Bernard Chasekwa, Sandra Rukobo, Margaret Govha, Benjamin Lee, Marya P Carmolli, Robert Ntozini, Kuda Mutasa, Monica M McNeal, Florence D Majo and 5 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01824940 (Sanitation, Hygiene, Infant Nutrition Efficacy Project), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01824940 nacompletednot on this map

Sanitation, Hygiene, Infant Nutrition Efficacy Project

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2012 to 2017Enrolled5,280ConditionsGrowth, Stunting, Nutritional, AnemiaArmsStandard care, WASH, Infant and young child feeding, WASH and Nutrition
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Plasma Rotavirus-specific IgA and Risk of Rotavirus Vaccine Failure in Infants in Malawi.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

James A ChurchZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Centre for Genomics & Child Health, Blizard Institute, Queen Mary University of London, UK. Electronic address: j.church@qmul.ac.uk.
Bernard ChasekwaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Sandra RukoboZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Margaret GovhaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Benjamin LeeVaccine Testing Center, Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Marya P CarmolliVaccine Testing Center, Department of Microbiology & Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Robert NtoziniZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Kuda MutasaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Monica M McNealDepartment of Pediatrics, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Florence D MajoZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Naume V TavengwaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Beth D KirkpatrickVaccine Testing Center, Department of Microbiology & Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Lawrence H MoultonDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jean H HumphreyZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Andrew J PrendergastZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Centre for Genomics & Child Health, Blizard Institute, Queen Mary University of London, UK; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: a.prendergast@qmul.ac.uk.
Zvitambo Institute for Maternal and Child Health Research · ZWJohns Hopkins University · USUniversity of Vermont · USCincinnati Children's Hospital Medical Center · USQueen Mary University of London · GB

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Ellen Kozelka · 2018 to 2026
$24.9M
Effect of a sanitation & nutrition intervention on HIV-exposed infant healthR01HD060338 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HUMPHREY, JEAN HAWES · 2008 to 2012
$2.0M
NICHD NIH HHS R01 HD060338NIGMS NIH HHS P20 GM125498Wellcome Trust 093768/Z/10/ZWellcome Trust 108065/Z/15/ZWellcome Trust 203905/Z/16/Z
6 · The paper itself

Abstract

backgroundOral rotavirus vaccines (RVV) have poor immunogenicity in low-income countries, for reasons that remain unclear. This study identified the determinants of RVV immunogenicity among infants in rural Zimbabwe.

methodsAnti-rotavirus IgA titres were measured among a sub-group of infants enrolled in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial (NCT01824940). SHINE was a cluster-randomized trial of improved infant and young child feeding, and improved water, sanitation and hygiene (WASH) in two rural Zimbabwean districts. Infants received RVV as part of the national immunisation programme. Among HIV-unexposed infants in the non-WASH trial arms, we evaluated associations between potential risk factors (vaccine schedule and dose, maternal and infant nutritional status, infant diarrhoea, and household environment) and RVV immunogenicity (seroconversion, seropositivity and geometric mean titres) using multivariable regression.

resultsAmong 219 infants with seroconversion data, 43 (20%) successfully seroconverted and 176 (80%) failed to seroconvert to RVV. Seroconversion was positively associated with a higher length-for-age Z-score (LAZ) around the time of vaccination (adjusted RR 1.27 (95% CI 1.04, 1.55), P = 0.021), and negatively associated with concurrent OPV and RVV administration (adjusted RR 0.36 (0.19, 0.71), P = 0.003). Among 472 infants with post-vaccination titres, a higher LAZ score was associated with increased seropositivity (aRR 1.21 (95% CI 1.06, 1.38), P = 0.004), and higher birthweight was associated with increased IgA titres (0.45 (95%CI 0.18, 1.09) U/mL greater per 100 g gain in birthweight; P = 0.001).

conclusionsInfant ponderal and linear growth were positively associated with RVV immunogenicity, while concurrent administration of OPV was negatively associated with RVV immunogenicity. Together, these findings suggest that improving foetal growth and separating RVV and OPV administration are plausible approaches to increasing RVV immunogenicity.

Indexed as

Immunogenicity, VaccineRotavirus InfectionsAntibodies, ViralChild, PreschoolFemaleHumansImmunoglobulin AInfantMalePregnancyRotavirusRotavirus VaccinesZimbabweAntibodies, ViralImmunoglobulin ARotavirus VaccinesAfricaImmunogenicityInfantsOral vaccineRotavirus

Identifiers

PMID32088018
PMCPMC7065039
OpenAlexW3007764585

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.