Evidence map›Paper›PMID 32087950›Full record

ReviewBiological psychiatry2020

Approaches to Defining Common and Dissociable Neurobiological Deficits Associated With Psychopathology in Youth.

Antonia N Kaczkurkin, Tyler M Moore, Aristeidis Sotiras, Cedric Huchuan Xia, Russell T Shinohara, Theodore D Satterthwaite

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

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  20. Neural signatures of data-driven psychopathology dimensions at the transition to adolescence.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Antonia N KaczkurkinDepartment of Psychology, Vanderbilt University, Nashville, Tennessee.
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Aristeidis SotirasDepartment of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri; Institute for Informatics, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Cedric Huchuan XiaDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Russell T ShinoharaDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
Theodore D SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: sattertt@pennmedicine.upenn.edu.
University of Pennsylvania · USVanderbilt University · USWashington University in St. Louis · US

Funding

Longitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9M
Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
Mapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern AnalysisR01MH112070 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2020
$2.7M
Longitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
Statistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8M
Multimodal brain maturation indices modulating psychopathology and neurocognitionR01MH107235 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2015 to 2017
$1.5M
Delineating neurobiological heterogeneity in internalizing symptoms using machine learning and deep phenotypingR00MH117274 · NIMH · VANDERBILT UNIVERSITY · PI KACZKURKIN, ANTONIA · 2019 to 2021
$729k
Delineating neurobiological heterogeneity in internalizing symptoms using machine learning and deep phenotypingK99MH117274 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KACZKURKIN, ANTONIA · 2018 to 2019
$122k
NIBIB NIH HHS R01 EB022573NIMH NIH HHS K99 MH117274NIMH NIH HHS R00 MH117274NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH112070NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH120482NINDS NIH HHS R01 NS085211NINDS NIH HHS R01 NS099348
6 · The paper itself

Abstract

Psychiatric disorders show high rates of comorbidity and nonspecificity of presenting clinical symptoms, while demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. We review progress and next steps in efforts to parse heterogeneity in psychiatric symptoms in youths by identifying abnormalities within neural circuits. To address this fundamental challenge in psychiatry, a number of methods have been proposed. We provide an overview of these methods, broadly organized into dimensional versus categorical approaches and single-view versus multiview approaches. Dimensional approaches including factor analysis and canonical correlation analysis aim to capture dimensional associations between psychopathology and brain measures across a continuous spectrum from health to disease. In contrast, categorical approaches, such as clustering and community detection, aim to identify subtypes of individuals within a class of symptoms or brain features. We highlight several studies that apply these methods to samples of youths and discuss issues to consider when using these approaches. Finally, we end by highlighting avenues for future research.

Indexed as

Mental DisordersPsychiatryAdolescentBrainComorbidityHumansPsychopathologyAdolescentsHeterogeneityImagingNeurobiologyPsychopathologyYouth

Identifiers

PMID32087950
PMCPMC7305976
OpenAlexW2996500655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.