ArticleAntimicrobial resistance and infection control2020
The appropriateness of antimicrobial use in the outpatient clinics of three hospitals in the Netherlands.
Article in Antimicrobial resistance and infection control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Patterns of antimicrobial use in Qatar's hospitals: Results from the first national point prevalence survey.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Development and assessment of the outpatient module of the Global-PPS: a standardized approach for measuring outpatient antimicrobial prescribing.JAC-antimicrobial resistance · 2025Article
- Antimicrobial Prescribing Patterns in Russian Outpatients in 2024: Results of the Global-PPS Project.Infection & chemotherapy · 2025Article
- Prescriber-level surveillance of outpatient antimicrobial consumption to enable targeted antimicrobial stewardship: a nationwide observational study, Switzerland, 2015 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Observational
- Antibiotic appropriateness at outpatient settings in Ethiopia: the need for an antibiotic stewardship programme.Drugs in context · 2024Article
- The Challenge of Overcoming Antibiotic Resistance in Carbapenem-Resistant Gram-Negative Bacteria: "Attack on Titan".Microorganisms · 2023Review
- Impact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- Antibiotic Prescriptions for Respiratory Tract Viral Infections in the Colombian Population.Antibiotics (Basel, Switzerland) · 2021Article
- Appropriate Antibiotic Use and Associated Factors in Vietnamese Outpatients.Healthcare (Basel, Switzerland) · 2021Article
- Evaluation of children's antibiotics use for outpatient pneumonia treatment in Vietnam.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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7 authors.
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Abstract
objectivesAntimicrobial Stewardship Programs commonly have an in-hospital focus. Little is known about the quality of antimicrobial use in hospital outpatient clinics. We investigated the extent and appropriateness of antimicrobial prescriptions in the outpatient clinics of three hospitals.
methodsFrom June 2018 to January 2019, we performed ten point prevalence surveys in outpatient clinics of one university hospital and two large teaching hospitals. All prophylactic and therapeutic prescriptions were retrieved from the electronic medical records. Appropriateness was defined as being in accordance with guidelines. Furthermore, we investigated the extent to which the dose was adjusted to renal function and documentation of an antibiotic plan in the case notes.
resultsWe retrieved 720 prescriptions for antimicrobial drugs, of which 173 prescriptions (24%) were prophylactic. A guideline was present for 95% of prescriptions, of which the guideline non-adherence rate was 25.6% (n = 42/164) for prophylaxis and 43.1% (n = 224/520) for therapy. Of all inappropriate prescriptions (n = 266), inappropriate prescriptions for skin and soft tissue infections (n = 60/226) and amoxicillin-clavulanic acid (n = 67/266) made up the largest proportion. In only 13 of 138 patients with impaired or unknown renal function the dosage regimen was adjusted. Amoxicillin-clavulanic acid was the drug for which most often renal function was not taken into account. In 94.6% of prescriptions the antibiotic plan was documented.
conclusionsIn hospital outpatient clinics, a substantial part of therapeutics were inappropriately prescribed. Amoxicillin-clavulanic acid was the most inappropriately prescribed drug, due to non-adherence to the guidelines and because dose adjustment to renal function was often not considered.
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