ArticleInternational journal of hygiene and environmental health2020
Prenatal pesticide exposure and childhood leukemia - A California statewide case-control study.
Article in International journal of hygiene and environmental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Passive environmental residential exposure to agricultural pesticides and hematological malignancies in the general population: a systematic review.Environmental science and pollution research international · 2021Pooled it
- Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies.International journal of cancer · 2026Article
- Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations.Environmental health perspectives · 2026Article
- Preventing Pesticide Toxicity Risk Through Self-Reported Practices in Children of Farming Communities: A Social Practice Theory Perspective.Journal of xenobiotics · 2026Article
- Establishing environmental causes of childhood cancer: a view from the IARC Monographs.UCL open. Environment · 2026Article
- Prenatal pesticide exposure and neuroblastoma - A statewide case-control study in California.Environmental research · 2025Article
- Personal air sampling for pesticides in the California San Joaquin Valley.Journal of exposure science & environmental epidemiology · 2025Article
- Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia.Cancers · 2025Article
- Article
- Evidence concerning parental exposure to pesticides and the occurrence of leukemia in offspring: a systematic review.Frontiers in pediatrics · 2025Review
- Residential proximity to agricultural herbicide and fungicide applications and dust levels in homes of California children.Environment international · 2024Article
- Widespread occurrence of pesticides in low-income housing.Journal of exposure science & environmental epidemiology · 2024Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Exposure to persistent organic pollutants in newborn dried blood spots and childhood acute myeloid leukemia.Environmental research · 2024Article
- Evaluating the accuracy of satellite-based methods to estimate residential proximity to agricultural crops.Journal of exposure science & environmental epidemiology · 2024Article
- Response to "Comment on 'Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013'".Environmental health perspectives · 2024Article
- Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013.Environmental health perspectives · 2023Article
- Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward.International journal of cancer · 2023Article
- Glyphosate in house dust and risk of childhood acute lymphoblastic leukemia in California.Environment international · 2023Article
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA number of epidemiologic studies with a variety of exposure assessment approaches have implicated pesticides as risk factors for childhood cancers. Here we explore the association of pesticide exposure in pregnancy and early childhood with childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) utilizing land use and pesticide use data in a sophisticated GIS tool.
methodsWe identified cancer cases less than 6 years of age from the California Cancer Registry and cancer-free controls from birth certificates. Analyses were restricted to those living in rural areas and born 1998-2011, resulting in 162 cases of childhood leukemia and 9,805 controls. Possible carcinogens were selected from the Environmental Protection Agency's classifications and pesticide use was collected from the California Department of Pesticide Regulation's (CDPR) Pesticide Use Reporting (PUR) system and linked to land-use surveys. Exposures for subjects were assessed using a 4000m buffer around the geocoded residential addresses at birth. Unconditional logistic and hierarchical regression models were used to assess individual pesticide and pesticide class associations.
resultsWe observed elevated risks for ALL with exposure to any carcinogenic pesticide (adjusted Odds Ratio (aOR): 2.83, 95% CI: 1.67-4.82), diuron (Single-pesticide model, adjusted (OR): 2.38, 95% CI: 1.57-3.60), phosmet (OR: 2.10, 95% CI: 1.46-3.02), kresoxim-methyl (OR: 1.77, 95% CI: 1.14-2.75), and propanil (OR: 2.58, 95% CI: 1.44-4.63). Analyses based on chemical classes showed elevated risks for the group of 2,6-dinitroanilines (OR: 2.50, 95% CI: 1.56-3.99), anilides (OR: 2.16, 95% CI: 1.38-3.36), and ureas (OR: 2.18, 95% CI: 1.42-3.34).
conclusionOur findings suggest that in rural areas of California exposure to certain pesticides or pesticide classes during pregnancy due to residential proximity to agricultural applications may increase the risk of childhood ALL and AML. Future studies into the mechanisms of carcinogenicity of these pesticides may be beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.