Evidence map›Paper›PMID 32087200›Full record

ReviewJournal of molecular biology2020

A Theoretical Framework for Evolutionary Cell Biology.

Michael Lynch, Bogi Trickovic

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Energetics and evolution: Response to Martin.Biochimica et biophysica acta. Bioenergetics · 2026
    Article
  3. Evolutionary cell biology comes of age.Journal of cell science · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Bioenergetics and the Evolution of Cellular Traits.Annual review of biophysics · 2025
    Review
  8. Article
  9. Flagellar motility is mutagenic.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Flagellar Motility is Mutagenic.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Article
  13. Mutation pressure, drift, and the pace of molecular coevolution.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Evolutionary bioenergetics of ciliates.The Journal of eukaryotic microbiology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cell types as species: Exploring a metaphor.Frontiers in plant science · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael LynchBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, 85287, USA. Electronic address: mlynch11@asu.edu.
Bogi TrickovicBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, 85287, USA.

Funding

Causes and Population-genetic Consequences of Molecular VariationR35GM122566 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael R LYNCH · 2017 to 2026
$7.7M
NIGMS NIH HHS R35 GM122566
6 · The paper itself

Abstract

One of the last uncharted territories in evolutionary biology concerns the link with cell biology. Because all phenotypes ultimately derive from events at the cellular level, this connection is essential to building a mechanism-based theory of evolution. Given the impressive developments in cell biological methodologies at the structural and functional levels, the potential for rapid progress is great. The primary challenge for theory development is the establishment of a quantitative framework that transcends species boundaries. Two approaches to the problem are presented here: establishing the long-term steady-state distribution of mean phenotypes under specific regimes of mutation, selection, and drift and evaluating the energetic costs of cellular structures and functions. Although not meant to be the final word, these theoretical platforms harbor potential for generating insight into a diversity of unsolved problems, ranging from genome structure to cellular architecture to aspects of motility in organisms across the Tree of Life.

Indexed as

Biological EvolutionCell BiologyModels, TheoreticalAnimalsArchaeaBacteriaEukaryotaHumansbacterial envelopebioenergetic costscell motilityevolutionary cell biologypopulation genetics

Identifiers

PMID32087200
PMCPMC8025685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.