ArticleHuman brain mapping2020
Alterations and test-retest reliability of functional connectivity network measures in cerebral small vessel disease.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- The Impact of Denoising Approaches on the Relationship Between Alzheimer's Disease Diagnostic Status and Network Topology Measures.Human brain mapping · 2026Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Impact of Anesthesia on Brain Functional Networks in Moyamoya Disease and Spinal Lesions.CNS neuroscience & therapeutics · 2025Article
- Article
- Functional MRI brain state occupancy in the presence of cerebral small vessel diseaseImaging neuroscience (Cambridge, Mass.) · 2024Article
- Cortical Thickness and Brain Connectivity Mediate the Relation Between White Matter Hyperintensity and Information Processing Speed in Cerebral Small Vessel Disease.Brain topography · 2023Article
- Evaluating test-retest reliability and sex-/age-related effects on temporal clustering coefficient of dynamic functional brain networks.Human brain mapping · 2023Article
- Advanced MRI in cerebral small vessel disease.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Reproducibility of regional structural and functional MRI networks in cerebral small vessel disease compared to age matched and stroke-free controls.Cerebral circulation - cognition and behavior · 2023Article
- Functional connectivity in older adults-the effect of cerebral small vessel disease.Brain communications · 2023Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
- Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived fromKorean journal of radiology · 2022Article
- The Hyperintense study: Assessing the effects of induced blood pressure increase and decrease on MRI markers of cerebral small vessel disease: Study rationale and protocol.European stroke journal · 2022Article
- Systematic validation of structural brain networks in cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Imaging Markers of Vascular Brain Health: Quantification, Clinical Implications, and Future Directions.Stroke · 2022Review
- The Clustering Analysis of Time Properties in Patients With Cerebral Small Vessel Disease: A Dynamic Connectivity Study.Frontiers in neurology · 2022Article
- Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the "ZOOM@SVDs" study.Cerebral circulation - cognition and behavior · 2021Article
- Alterations and test-retest reliability of functional connectivity network measures in cerebral small vessel disease.Human brain mapping · 2020Article
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Authors and funding
18 authors at 4 institutions in 4 countries.
Funding
Abstract
While structural network analysis consolidated the hypothesis of cerebral small vessel disease (SVD) being a disconnection syndrome, little is known about functional changes on the level of brain networks. In patients with genetically defined SVD (CADASIL, n = 41) and sporadic SVD (n = 46), we independently tested the hypothesis that functional networks change with SVD burden and mediate the effect of disease burden on cognitive performance, in particular slowing of processing speed. We further determined test-retest reliability of functional network measures in sporadic SVD patients participating in a high-frequency (monthly) serial imaging study (RUN DMC-InTENse, median: 8 MRIs per participant). Functional networks for the whole brain and major subsystems (i.e., default mode network, DMN; fronto-parietal task control network, FPCN; visual network, VN; hand somatosensory-motor network, HSMN) were constructed based on resting-state multi-band functional MRI. In CADASIL, global efficiency (a graph metric capturing network integration) of the DMN was lower in patients with high disease burden (standardized beta = -.44; p [corrected] = .035) and mediated the negative effect of disease burden on processing speed (indirect path: std. beta = -.20, p = .047; direct path: std. beta = -.19, p = .25; total effect: std. beta = -.39, p = .02). The corresponding analyses in sporadic SVD showed no effect. Intraclass correlations in the high-frequency serial MRI dataset of the sporadic SVD patients revealed poor test-retest reliability and analysis of individual variability suggested an influence of age, but not disease burden, on global efficiency. In conclusion, our results suggest that changes in functional connectivity networks mediate the effect of SVD-related brain damage on cognitive deficits. However, limited reliability of functional network measures, possibly due to age-related comorbidities, impedes the analysis in elderly SVD patients.
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